Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.35 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PADI4 | Q9UM07 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2276772 | 0.85 | ABCG2 (0.47) | ABCG2NPC1RAB9ACYP19A1CYP2C9 | |
| SCHEMBL2276769 | 0.85 | ABCG2 (0.47) | ABCG2NPC1RAB9ACYP19A1CYP2C9 | |
| SCHEMBL13403298 | 0.82 | RAB9A (0.57) | ABCG2NPC1PKMRAB9ASLC5A1 | |
| SCHEMBL12374853 | 0.81 | PADI4 (0.49) | NPC1RAB9APADI4L3MBTL1KDM4E | |
| SCHEMBL2284265 | 0.80 | APP (0.48) | ABCG2NPC1PKMRAB9ASLC5A1 | |
| SCHEMBL2284270 | 0.80 | APP (0.48) | ABCG2NPC1PKMRAB9ASLC5A1 | |
| SCHEMBL13818099 | 0.79 | PADI4 (0.38) | NPC1RAB9ACYP2C9CYP2C19PADI4 | |
| SCHEMBL2283102 | 0.76 | CYSLTR2 (0.46) | ABCG2NPC1RAB9ACYP2C9MAOB | |
| SCHEMBL2283107 | 0.76 | CYSLTR2 (0.46) | ABCG2NPC1RAB9ACYP2C9MAOB | |
| SCHEMBL2283908 | 0.75 | ABCG2 (0.47) | ABCG2CYP19A1CYP2C9MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989478-B2 | decreases expression of a Type I collage gene in a tissue to induce a reduction in accumulation of collagen and thereby improves tissue fibrosis | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-08-02 | — | — | US | disclosed |
| US-7989478-B2 | decreases expression of a Type I collage gene in a tissue to induce a reduction in accumulation of collagen and thereby improves tissue fibrosis | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-08-02 | — | — | US | disclosed |