Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13818097 | 0.88 | PADI4 (0.40) | MEN1KMT2AKDM4EPKMSMN1; SMN2 | |
| SCHEMBL13403305 | 0.82 | KDM4E (0.50) | MEN1KMT2AKDM4ERAB9AMAPT | |
| SCHEMBL2277602 | 0.82 | LMNA (0.40) | MEN1KMT2AKDM4ERAB9ANPC1 | |
| SCHEMBL2277607 | 0.82 | LMNA (0.40) | MEN1KMT2AKDM4ERAB9ANPC1 | |
| SCHEMBL2279527 | 0.81 | PADI4 (0.53) | MEN1KMT2AUSP2KDM4ERAB9A | |
| SCHEMBL2279523 | 0.81 | PADI4 (0.53) | MEN1KMT2AUSP2KDM4ERAB9A | |
| SCHEMBL2277539 | 0.81 | MEN1 (0.49) | MEN1KMT2AUSP2KDM4ERAB9A | |
| SCHEMBL2277535 | 0.81 | MEN1 (0.49) | MEN1KMT2AUSP2KDM4ERAB9A | |
| SCHEMBL4520101 | 0.78 | PADI4 (0.40) | USP2KDM4ERAB9ANPC1NLRP3 | |
| SCHEMBL4520097 | 0.78 | PADI4 (0.40) | USP2KDM4ERAB9ANPC1NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989478-B2 | decreases expression of a Type I collage gene in a tissue to induce a reduction in accumulation of collagen and thereby improves tissue fibrosis | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-08-02 | — | — | US | disclosed |
| US-7989478-B2 | decreases expression of a Type I collage gene in a tissue to induce a reduction in accumulation of collagen and thereby improves tissue fibrosis | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-08-02 | — | — | US | disclosed |