Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.41 |
| ▸ | RAF1 | P04049 | 5/20 | 0.41 |
| ▸ | MET | P08581 | 8/20 | 0.38 |
| ▸ | BRD4 | O60885 | 3/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12377502 | 0.82 | DYRK1A (0.54) | DYRK1ARAF1METMAPK14 | |
| SCHEMBL12377530 | 0.81 | DYRK1A (0.42) | DYRK1ARAF1METMAPK14KDM4E | |
| SCHEMBL2286657 | 0.80 | MET (0.63) | NSD3DYRK1ARAF1METBRD4 | |
| SCHEMBL12377494 | 0.77 | RAF1 (0.63) | DYRK1ARAF1METMAPK14 | |
| SCHEMBL12377508 | 0.75 | MET (0.63) | DYRK1ARAF1METMAPK14 | |
| SCHEMBL12377497 | 0.75 | DYRK1A (0.49) | DYRK1ARAF1METMAPK14 | |
| SCHEMBL12377503 | 0.75 | MET (0.63) | DYRK1ARAF1METMAPK14 | |
| SCHEMBL12377501 | 0.74 | DYRK1A (0.44) | DYRK1ARAF1METMAPK14 | |
| SCHEMBL12377493 | 0.73 | MET (0.65) | DYRK1ARAF1METMAPK14 | |
| SCHEMBL12377518 | 0.73 | MET (0.53) | DYRK1ARAF1METMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110207732-A1 | AZAINDOLE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207732-A1 | AZAINDOLE DERIVATIVES | AZI2, ABL1, RET | NSD3 248/4885DYRK1A 153/4885RAF1 281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.