SCHEMBL12377552

SCHEMBL12377552

C/C(=C\CC/C(C)=C/CC/C(C)=C/COCc1ccccc1)CBr

nearest known ligand 0.57

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
LSS P48449 2/20 0.51
TRPV1 Q8NER1 2/20 0.47
ICMT O60725 1/20 0.39
TSHR P16473 1/20 0.39
ALOX5 P09917 1/20 0.36
ALOX15 P16050 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7462714 0.91 TSHR (0.47) LSSTRPV1TSHRALOX5
SCHEMBL7462710 0.91 TSHR (0.47) LSSTRPV1TSHRALOX5
SCHEMBL11039511 0.88 TRPV1 (0.59) LSSTRPV1ICMTALOX15
SCHEMBL11039509 0.88 TRPV1 (0.59) LSSTRPV1ICMTALOX15
SCHEMBL12377556 0.88 TRPV1 (0.59) LSSTRPV1ICMTALOX15
SCHEMBL1072282 0.87 LSS (0.52) LSSTRPV1ICMTTSHR
SCHEMBL12377555 0.87 LSS (0.52) LSSTRPV1ICMTTSHR
SCHEMBL1072281 0.87 LSS (0.52) LSSTRPV1ICMTTSHR
SCHEMBL10981275 0.87 LSS (0.52) LSSTRPV1ICMTTSHR
SCHEMBL10981272 0.87 LSS (0.52) LSSTRPV1ICMTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3018116-B1 VITAMIN K2 INTERMEDIATES KAPPA BIOSCIENCE AS (NO) 2020-10-28 EP disclosed
US-20170283354-A1 PROCESS FOR THE PREPARATION OF VITAMIN K2 KAPPA BIOSCIENCE AS (NO) 2017-10-05 US disclosed
US-20170283354-A1 PROCESS FOR THE PREPARATION OF VITAMIN K2 KAPPA BIOSCIENCE AS (NO) 2017-10-05 US disclosed
EP-3018116-A1 VITAMIN K2 INTERMEDIATES Kappa Bioscience As (NO) 2016-05-11 EP disclosed
EP-2346806-B1 PROCESS FOR THE PREPARATION OF VITAMIN K2 KAPPA BIOSCIENCE AS (NO) 2016-01-06 EP disclosed
US-20150210620-A1 PROCESS FOR THE PREPARATION OF VITAMIN K2 KAPPA BIOSCIENCE AS (NO) 2015-07-30 US disclosed
US-20150210620-A1 PROCESS FOR THE PREPARATION OF VITAMIN K2 KAPPA BIOSCIENCE AS (NO) 2015-07-30 US disclosed
US-9012693-B2 Process for the preparation of vitamin K2 KAPPA BIOSCIENCE AS (NO) 2015-04-21 US disclosed
US-9012693-B2 Process for the preparation of vitamin K2 KAPPA BIOSCIENCE AS (NO) 2015-04-21 US disclosed
US-20110207967-A1 PROCESS FOR THE PREPARATION OF VITAMIN K2 KAPPA BIOSCIENCE AS (NO) 2011-08-25 US disclosed
US-20110207967-A1 PROCESS FOR THE PREPARATION OF VITAMIN K2 KAPPA BIOSCIENCE AS (NO) 2011-08-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170283354-A1 PROCESS FOR THE PREPARATION OF VITAMIN K2 PROC, VKORC1, VKORC1L1 LSS 305/4885TRPV1 4664/4885ICMT 1796/4885
US-20110207967-A1 PROCESS FOR THE PREPARATION OF VITAMIN K2 PROC, VKORC1, VKORC1L1 LSS 290/4885TRPV1 4743/4885ICMT 1710/4885
US-20150210620-A1 PROCESS FOR THE PREPARATION OF VITAMIN K2 PROC, VKORC1, VKORC1L1 LSS 305/4885TRPV1 4664/4885ICMT 1796/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.