SCHEMBL12377626

SCHEMBL12377626

Cc1ccc(-c2ccc(C)c(F)c2)cc1F

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NISCH Q9Y2I1 1/20 0.52
ERN1 O75460 1/20 0.47
KMO O15229 2/20 0.46
ACHE P22303 1/20 0.46
AKR1C3 P42330 2/20 0.44
AKR1C2 P52895 2/20 0.44
HDAC1 Q13547 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
AKR1B10 O60218 1/20 0.42
AKR1C4 P17516 1/20 0.42
AKR1C1 Q04828 1/20 0.42
ALDH1A1 P00352 1/20 0.42
CYP3A4 P08684 1/20 0.42
TSHR P16473 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
KCNH2 Q12809 2/20 0.41
SLC6A3 Q01959 1/20 0.41
PDE3B Q13370 1/20 0.39
PDE3A Q14432 1/20 0.39
TNKS2 Q9H2K2 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13703909 0.97 NISCH (0.50) NISCHERN1KMOACHEAKR1C3
SCHEMBL12446947 0.92 NISCH (0.47) NISCHERN1KMOACHEAKR1C3
SCHEMBL10269392 0.92 NISCH (0.47) NISCHERN1KMOACHEAKR1C3
SCHEMBL13906282 0.90 TNKS2 (0.50) NISCHERN1KMOACHEAKR1C3
SCHEMBL10018704 0.90 NISCH (0.46) NISCHERN1KMOACHEAKR1C3
SCHEMBL13104728 0.90 NISCH (0.46) NISCHERN1KMOACHEAKR1C3
SCHEMBL10014184 0.90 NISCH (0.46) NISCHERN1KMOACHEAKR1C3
SCHEMBL23173084 0.88 AKR1C3 (0.58) NISCHERN1KMOAKR1C3AKR1C2
SCHEMBL30180898 0.88 ACHE (0.48) NISCHERN1KMOACHEAKR1C3
SCHEMBL10304803 0.88 NISCH (0.44) NISCHERN1KMOACHEAKR1C3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 478 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11667840-B2 Liquid-crystalline medium MERCK PATENT GMBH (DE) 2023-06-06 US disclosed
US-20230131540-A1 LIQUID CRYSTAL COMPOSITION, LIQUID CRYSTAL DISPLAY ELEMENT AND COMPOUND DIC CORPORATION (JP) 2023-04-27 US disclosed
US-11466211-B2 Liquid crystal composition and liquid crystal display element including the same DIC CORPORATION (JP) 2022-10-11 US disclosed
EP-2907864-B2 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY ELEMENT USING THIS COMPOSITION DAINIPPON INK & CHEMICALS (JP) 2022-05-18 EP disclosed
US-20210139730-A1 DISPERSION AND INKJET INK COMPOSITION, LIGHT CONVERSION LAYER, AND LIQUID CRYSTAL DISPLAY ELEMENT USING THE DISPERSION DIC CORPORATION (JP) 2021-05-13 US disclosed
US-10947403-B2 Dispersion and inkjet ink composition, light conversion layer, and liquid crystal display element using the dispersion DIC CORPORATION (JP) 2021-03-16 US disclosed
US-10934488-B2 Polymerizable compound-containing liquid crystal composition and liquid crystal display device using the same DIC CORPORATION (JP) 2021-03-02 US disclosed
US-20210026206-A1 LIQUID CRYSTAL DISPLAY DEVICE DIC CORPORATION (JP) 2021-01-28 US disclosed
US-10883047-B2 Liquid-crystalline medium and liquid-crystal display comprising the same MERCK PATENT GMBH (DE) 2021-01-05 US disclosed
US-10788715-B2 Photo-alignment material and photo-alignment method TOKYO INSTITUTE OF TECHNOLOGY (JP) 2020-09-29 US disclosed
EP-2684935-A1 NEMATIC LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY ELEMENT USING SAME DIC Corporation (JP) 2014-01-15 EP disclosed
EP-2657318-A1 LIQUID CRYSTAL COMPOSITION CONTAINING POLYMERIZABLE COMPOUND, AND LIQUID CRYSTAL DISPLAY ELEMENT UTILIZING SAME DIC Corporation (JP) 2013-10-30 EP disclosed
US-8350100-B2 Process for the preparation of ring compounds MERCK PATENT GMBH (DE) 2013-01-08 US disclosed
US-8350100-B2 Process for the preparation of ring compounds MERCK PATENT GMBH (DE) 2013-01-08 US disclosed
US-20120292568-A1 LIQUID CRYSTAL COMPOSITION CONTAINING POLYMERIZABLE COMPOUND AND LIQUID CRYSTAL DISPLAY ELEMENT MANUFACTURED USING THE SAME DIC CORPORATION (JP) 2012-11-22 US disclosed
US-20120292568-A1 LIQUID CRYSTAL COMPOSITION CONTAINING POLYMERIZABLE COMPOUND AND LIQUID CRYSTAL DISPLAY ELEMENT MANUFACTURED USING THE SAME DIC CORPORATION (JP) 2012-11-22 US disclosed
US-8003287-B2 Low temperature charge transportability and potential, sensitivity and photoresponsiveness; durability SHARP KABUSHIKI KAISHA (JP) 2011-08-23 US disclosed
US-8003287-B2 Low temperature charge transportability and potential, sensitivity and photoresponsiveness; durability SHARP KABUSHIKI KAISHA (JP) 2011-08-23 US disclosed
US-20080166642-A1 Electrophotographic photoconductor and image-forming apparatus SHARP KABUSHIKI KAISHA (JP) 2008-07-10 US disclosed
US-20080166642-A1 Electrophotographic photoconductor and image-forming apparatus SHARP KABUSHIKI KAISHA (JP) 2008-07-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11667840-B2 Liquid-crystalline medium FES, BLM, CXCL12 NISCH 334/4885ERN1 4125/4885KMO 2499/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.