⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9892907 | 0.73 | — | — | |
| SCHEMBL1518 | 0.70 | — | — | |
| SCHEMBL11789213 | 0.67 | — | — | |
| SCHEMBL10939131 | 0.67 | — | — | |
| SCHEMBL9475016 | 0.67 | — | — | |
| SCHEMBL377192 | 0.67 | — | — | |
| SCHEMBL1016 | 0.65 | — | — | |
| SCHEMBL6739107 | 0.64 | — | — | |
| SCHEMBL248844 | 0.64 | — | — | |
| Hydrochloric Acid SCHEMBL9475020 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230381330-A1 | ENZYME-ACTIVATED SERUM EXTENDED HALF-LIFE THERAPEUTIC CONJUGATES | AVACTA LIFE SCIENCES LIMITED (GB) | 2023-11-30 | — | — | US | disclosed |
| US-11826328-B2 | Stable treprostinil prodrugs | UNITED THERAPEUTICS CORPORATION (US) | 2023-11-28 | — | — | US | disclosed |
| US-20230372372-A1 | COMBINATION THERAPIES USING CASPASE-1 DEPENDENT ANTICANCER AGENTS AND PGE2 ANTAGONISTS | TRUSTEES OF TUFTS COLLEGE | 2023-11-23 | — | — | US | disclosed |
| WO-2020043122-A1 | QUINAZOLINE DERIVATIVES AS RIP2 KINASE INHIBITOR | 南京明德新药研发有限公司 | 2020-03-05 | — | — | WO | disclosed |
| US-9956297-B2 | FAP-activated proteasome inhibitors for treating solid tumors | TRUSTEES OF TUFTS COLLEGE (US) | 2018-05-01 | — | — | US | disclosed |
| US-9597410-B2 | FAP-activated proteasome inhibitors for treating solid tumors | TRUSTEES OF TUFTS COLLEGE (US) | 2017-03-21 | — | — | US | disclosed |
| US-20160346401-A1 | FAP-Activated Proteasome Inhibitors for Treating Solid Tumors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-12-01 | — | — | US | disclosed |
| US-20160250237-A1 | SOFT PROTEASE INHIBITORS AND PRO-SOFT FORMS THEREOF | BACH BIOSCIENCES, LLC | 2016-09-01 | — | — | US | disclosed |
| US-20140255300-A1 | FAP-Activated Proteasome Inhibitors for Treating Solid Tumors | TRUSTEES OF TUFTS COLLEGE (US) | 2014-09-11 | — | — | US | disclosed |
| US-8003287-B2 | Low temperature charge transportability and potential, sensitivity and photoresponsiveness; durability | SHARP KABUSHIKI KAISHA (JP) | 2011-08-23 | — | — | US | disclosed |
| US-20090082309-A1 | Inhibiting dipeptidylpeptidase proteolysis of glucagon-like peptide 1 by conjointly administering to the animal metformin and an inhibitor of dipeptidylpeptidase IV; treating Type II diabetes but not sufficient to suppress the immune system of the animal | TRUSTEES OF TUFTS COLLEGE (US) | 2009-03-26 | — | — | US | disclosed |
| US-7429439-B2 | Electrophotographic photoreceptor and image forming apparatus provided with the same | SHARP KABUSHIKI KAISHA (JP) | 2008-09-30 | — | — | US | disclosed |
| US-20080166642-A1 | Electrophotographic photoconductor and image-forming apparatus | SHARP KABUSHIKI KAISHA (JP) | 2008-07-10 | — | — | US | disclosed |
| US-7157581-B2 | Monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them | DR. REDDY'S LABORATORIES LTD. (IN) | 2007-01-02 | — | — | US | disclosed |