Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.48 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.48 |
| ▸ | GLS | O94925 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2722768 | 0.83 | SMN1; SMN2 (0.59) | SMN1; SMN2HTTLMNANPSR1L3MBTL1 | |
| SCHEMBL10205809 | 0.83 | SMN1; SMN2 (0.52) | SMN1; SMN2HTTLMNANPSR1L3MBTL1 | |
| SCHEMBL9829124 | 0.79 | SMN1; SMN2 (0.68) | SMN1; SMN2HTTLMNANPSR1L3MBTL1 | |
| SCHEMBL3867684 | 0.79 | SMN1; SMN2 (0.55) | SMN1; SMN2HTTLMNANPSR1L3MBTL1 | |
| SCHEMBL8572144 | 0.77 | HDAC4 (0.59) | SMN1; SMN2HTTLMNANPSR1L3MBTL1 | |
| SCHEMBL20060916 | 0.77 | SMN1; SMN2 (0.65) | SMN1; SMN2HTTLMNANPSR1L3MBTL1 | |
| SCHEMBL14067363 | 0.75 | SMN1; SMN2 (0.68) | SMN1; SMN2HTTLMNANPSR1L3MBTL1 | |
| SCHEMBL9831308 | 0.74 | SMN1; SMN2 (0.61) | SMN1; SMN2HTTLMNANPSR1L3MBTL1 | |
| SCHEMBL890180 | 0.74 | AKR1C1 (0.57) | LMNAPKMHDAC4ALDH1A1HSD11B1 | |
| SCHEMBL3866449 | 0.73 | SMN1; SMN2 (0.60) | SMN1; SMN2HTTLMNANPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998978-B2 | Substituted 2-amino-fused heterocyclic compounds | PFIZER INC. (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | SMN1; SMN2 2141/4885HTT 3140/4885LMNA 3558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.