Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.45 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.45 |
| ▸ | GLS | O94925 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12378818 | 0.83 | SMN1; SMN2 (0.56) | SMN1; SMN2HTTLMNANPSR1L3MBTL1 | |
| SCHEMBL2722768 | 0.79 | SMN1; SMN2 (0.59) | SMN1; SMN2HTTLMNANPSR1L3MBTL1 | |
| SCHEMBL19531832 | 0.76 | ALDH1A1 (0.79) | SMN1; SMN2HTTLMNANPSR1L3MBTL1 | |
| SCHEMBL9829124 | 0.75 | SMN1; SMN2 (0.68) | SMN1; SMN2HTTLMNANPSR1L3MBTL1 | |
| SCHEMBL3867684 | 0.75 | SMN1; SMN2 (0.55) | SMN1; SMN2HTTLMNANPSR1L3MBTL1 | |
| SCHEMBL8572144 | 0.73 | HDAC4 (0.59) | SMN1; SMN2HTTLMNANPSR1L3MBTL1 | |
| SCHEMBL888702 | 0.73 | AKR1C1 (0.52) | LMNAALDH1A1PKMHDAC4OPRM1 | |
| SCHEMBL24571816 | 0.73 | ALDH1A1 (0.61) | SMN1; SMN2HTTLMNANPSR1L3MBTL1 | |
| SCHEMBL9830132 | 0.73 | ALDH1A1 (0.61) | SMN1; SMN2HTTLMNAALDH1A1PKM | |
| SCHEMBL9830124 | 0.73 | ALDH1A1 (0.61) | SMN1; SMN2HTTLMNAALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035194-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 2012-02-09 | — | — | US | disclosed |
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035194-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | SMN1; SMN2 2141/4885HTT 3140/4885LMNA 3558/4885 |
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | SMN1; SMN2 2141/4885HTT 3140/4885LMNA 3558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.