Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.49 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 5/20 | 0.43 |
| ▸ | MAPK7 | Q13164 | 5/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.40 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 2/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CLK3 | P49761 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL558762 | 0.82 | LCK (0.42) | MAPK14LCKEGFRINSRPDGFRB | |
| SCHEMBL10166210 | 0.82 | LCK (0.42) | MAPK14LCKEGFRINSRPDGFRB | |
| SCHEMBL558761 | 0.82 | LCK (0.42) | MAPK14LCKEGFRINSRPDGFRB | |
| SCHEMBL558920 | 0.82 | LCK (0.42) | MAPK14LCKEGFRINSRPDGFRB | |
| SCHEMBL559465 | 0.81 | HCAR3 (0.44) | MAPK14LCKEGFRINSRPDGFRB | |
| SCHEMBL10166205 | 0.81 | HCAR3 (0.44) | MAPK14LCKEGFRINSRPDGFRB | |
| SCHEMBL559464 | 0.81 | HCAR3 (0.44) | MAPK14LCKEGFRINSRPDGFRB | |
| SCHEMBL10166201 | 0.75 | TYRO3 (0.43) | MAPK14CCNT1 | |
| SCHEMBL558941 | 0.75 | TYRO3 (0.43) | MAPK14CCNT1 | |
| SCHEMBL558940 | 0.75 | TYRO3 (0.43) | MAPK14CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998978-B2 | Substituted 2-amino-fused heterocyclic compounds | PFIZER INC. (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | MAPK14 65/4885LCK 101/4885EGFR 455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.