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HCAR3

Hydroxycarboxylic acid receptor 3 · P49019 · HCAR3 on Sugi Atlas →

41,170 patent compounds predicted against HCAR3, 21,252 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL185895 SCHEMBL185895 1.00 18/20
SCHEMBL186420 SCHEMBL186420 1.00 18/20
SCHEMBL186474 SCHEMBL186474 1.00 18/20
SCHEMBL158601 SCHEMBL158601 0.67 17/20
SCHEMBL82675 SCHEMBL82675 0.68 16/20
SCHEMBL321911 SCHEMBL321911 1.00 15/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL321637) 0.97 15/20
SCHEMBL24032 SCHEMBL24032 1.00 14/20
SCHEMBL71308 SCHEMBL71308 1.00 14/20
SCHEMBL581227 SCHEMBL581227 0.73 14/20
SCHEMBL400483 SCHEMBL400483 0.62 14/20
SCHEMBL192101 SCHEMBL192101 0.58 14/20
SCHEMBL401028 SCHEMBL401028 0.67 13/20
SCHEMBL504055 SCHEMBL504055 0.64 13/20
SCHEMBL425321 SCHEMBL425321 0.58 13/20
SCHEMBL40979 SCHEMBL40979 0.54 13/20
SCHEMBL177446 SCHEMBL177446 0.53 13/20
Acifran Acifran (SCHEMBL188221) 1.00 12/20
SCHEMBL599138 SCHEMBL599138 1.00 12/20
SCHEMBL506550 SCHEMBL506550 0.74 12/20

Clinical trials — most relevant to HCAR3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell. PHASE4UNKNOWN
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin PHASE2UNKNOWN
Psychopharmacology for Cocaine Dependence - Buspirone PHASE2COMPLETED
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY PHASE1COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Satiation Peptides PHASE1COMPLETED
FFAR Agonist on Incretins, Insulin, Lipids and Inflammation nanCOMPLETED
Oat Bran and Plasma Lipid and Fecal Bacteria in Coronary Artery Disease Patients nanCOMPLETED
Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans. nanCOMPLETED
RCT to Describe the Effects of Colon Delivered Acetate, Propionate and Butyrate on Satiety and Glucose Homeostasis nanCOMPLETED
Investigating Optimal Propionate Delivery to the Colon Using Stable Isotope Labeling nanCOMPLETED
Metabotropic Receptors For Glutamate Type 3 In Parkinson's nanUNKNOWN
Genes, Omega-3 Fatty Acids and Cardiovascular Disease Risk Factors nanACTIVE_NOT_RECRUITING
A Positional Cloning Study on Schizophrenia nanCOMPLETED
Characterization of Breg Cells nanCOMPLETED
Characterizing a 5P-Linked BHR Susceptibility Locus nanCOMPLETED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish) nanUNKNOWN
In Vivo Assessment of Histamine Pharmacodynamics nanWITHDRAWN
Applying Systems Immunology to the Search for Personalized Biomarkers of Clinical Efficacy nanCOMPLETED
Gut Microbiome Analysis in Organ Transplant Recipient nanNOT_YET_RECRUITING
Family Blood Pressure Program - HyperGEN nanCOMPLETED
Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms nanCOMPLETED
Molecular Evaluation of TAAR1 and JAK/STAT Pathway in Hidradenitis Suppurativa nanCOMPLETED
Stress and Treatment Response in Puerto Rican Children With Asthma nanCOMPLETED
A Study of the Impact of Genetic Testing on Clinical Decision Making and Patient Care nanUNKNOWN
Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance nanUNKNOWN
Validation of Laser Doppler Flowmetry to Identify Allergic Rhinitis Patients With Pharmacogenetic Alterations in Histamine Metabolism nanCOMPLETED
Brain Receptors in Sympathetic Nervous System Regulation nanCOMPLETED
In Vitro Studies on Pharmacological Regulation and Genetic Risk Factors of Peripheral Human Nociceptors nanCOMPLETED
The Effect of PPI Therapy on Weight, Gut Microbiome, and Expression of GPR41 and GPR43 nanUNKNOWN
Inflammation Impact on Pain in Knee Osteoarthritis nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a HCAR3 binder may also engage these)

ProteinNameSimilarity
HCAR2 Hydroxycarboxylic acid receptor 2 0.996 landscape →
Q80Z39 — 0.996 Q80Z39 →
Q9EP66 — 0.993 Q9EP66 →
Q8C131 — 0.988 Q8C131 →
HCAR1 Hydroxycarboxylic acid receptor 1 0.985 landscape →
Q3U507 — 0.983 Q3U507 →
B0UXR0 — 0.982 B0UXR0 →
GPR174 Probable G-protein coupled receptor 174 0.980 landscape →
D4A7K7 — 0.979 D4A7K7 →
CYSLTR2 Cysteinyl leukotriene receptor 2 0.979 landscape →
Q9XSD4 — 0.979 Q9XSD4 →
P30558 — 0.978 P30558 →
B5X337 — 0.978 B5X337 →
Q9Z282 — 0.977 Q9Z282 →
A5PLE7 — 0.976 A5PLE7 →
GPR132 Probable G-protein coupled receptor 132 0.976 landscape →
Q61038 — 0.976 Q61038 →
P47749 — 0.976 P47749 →
GPR183 G-protein coupled receptor 183 0.975 landscape →
Q9R1K6 — 0.975 Q9R1K6 →
Q99MT7 — 0.975 Q99MT7 →
Q3U6B2 — 0.975 Q3U6B2 →
Q8BLG2 — 0.974 Q8BLG2 →
Q920E1 — 0.974 Q920E1 →
Q9GK76 — 0.974 Q9GK76 →
E7FEL0 — 0.973 E7FEL0 →
P21556 — 0.973 P21556 →
P60019 — 0.973 P60019 →
Q3UJF0 — 0.973 Q3UJF0 →
Q924T8 — 0.973 Q924T8 →