Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.76 |
| ▸ | TSHR | P16473 | 3/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.74 |
| ▸ | GAA | P10253 | 1/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 6/20 | 0.62 |
| ▸ | POLQ | O75417 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1008435 | 0.87 | LMNA (1.00) | LMNATSHRNPSR1GAATDP1 | |
| SCHEMBL20371480 | 0.85 | LMNA (1.00) | LMNATSHRNPSR1GAATDP1 | |
| SCHEMBL15708803 | 0.85 | LMNA (1.00) | LMNATSHRNPSR1GAATDP1 | |
| SCHEMBL12361570 | 0.85 | LMNA (0.71) | LMNATSHRNPSR1GAATDP1 | |
| SCHEMBL1006167 | 0.84 | LMNA (0.94) | LMNATSHRNPSR1GAATDP1 | |
| SCHEMBL14487346 | 0.82 | LMNA (0.67) | LMNATSHRNPSR1GAATDP1 | |
| SCHEMBL3451759 | 0.82 | LMNA (0.67) | LMNATSHRNPSR1GAATDP1 | |
| SCHEMBL13521109 | 0.80 | GRIA2 (0.71) | LMNATSHRNPSR1GAAMAPT | |
| SCHEMBL14555832 | 0.80 | LMNA (0.64) | LMNATSHRNPSR1GAATDP1 | |
| SCHEMBL14555306 | 0.80 | LMNA (0.63) | LMNATSHRNPSR1GAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998978-B2 | Substituted 2-amino-fused heterocyclic compounds | PFIZER INC. (US) | 2011-08-16 | — | — | US | disclosed |