SCHEMBL12383062

SCHEMBL12383062

CNc1cccc(NC(=O)c2cc(C(C)=O)cc(C(=O)Nc3cc(C(C)=O)cc(C(C)=O)c3)c2)c1

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 8/20 0.58
▸ MEN1 O00255 7/20 0.58
▸ MAPK1 P28482 2/20 0.58
▸ L3MBTL1 Q9Y468 1/20 0.58
▸ POLB P06746 2/20 0.56
▸ ALDH1A1 P00352 4/20 0.55
▸ NPC1 O15118 2/20 0.55
▸ RAB9A P51151 2/20 0.55
▸ SMN1; SMN2 Q16637 1/20 0.54
▸ NPSR1 Q6W5P4 1/20 0.54
▸ KCNK3 O14649 2/20 0.53
▸ KCNK9 Q9NPC2 2/20 0.53
▸ TOP1 P11387 1/20 0.53
▸ TOP2A P11388 1/20 0.53
▸ TOP2B Q02880 1/20 0.53
▸ HPGD P15428 1/20 0.52
▸ KCNH2 Q12809 1/20 0.51
▸ RXFP1 Q9HBX9 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24193768 0.97 KMT2A (0.57) KMT2AMEN1MAPK1L3MBTL1POLB
SCHEMBL13256343 0.91 KMT2A (0.54) KMT2AMEN1MAPK1L3MBTL1POLB
SCHEMBL13881267 0.91 KMT2A (0.57) KMT2AMEN1MAPK1L3MBTL1POLB
SCHEMBL1630322 0.90 KMT2A (0.63) KMT2AMEN1MAPK1L3MBTL1POLB
SCHEMBL13986876 0.87 KMT2A (0.68) KMT2AMEN1POLBALDH1A1NPC1
SCHEMBL5974770 0.87 KMT2A (0.73) KMT2AMEN1MAPK1L3MBTL1POLB
SCHEMBL13657050 0.87 KMT2A (0.60) KMT2AMEN1MAPK1L3MBTL1POLB
SCHEMBL17013407 0.85 KCNK3 (0.69) KMT2AMEN1L3MBTL1POLBKCNK3
SCHEMBL16883313 0.84 KMT2A (0.46) KMT2AMEN1MAPK1L3MBTL1POLB
SCHEMBL14081257 0.83 KMT2A (0.49) KMT2AMEN1MAPK1L3MBTL1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110203990-A1 CHLORINE RESISTANT POLYAMIDES AND MEMBRANES MADE FROM THE SAME MURPHY ANDREW PATRICK 2011-08-25 — — US disclosed
US-7806275-B2 Chlorine resistant polyamides and membranes made from the same THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE INTERIOR, THE BUREAU OF RECLAMATION (US) 2010-10-05 — — US disclosed
US-20080277333-A1 CHLORINE RESISTANT POLYAMIDES AND MEMBRANES MADE FROM THE SAME SEPARATION SYSTEMS TECHNOLOGY INC. 2008-11-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110203990-A1 CHLORINE RESISTANT POLYAMIDES AND MEMBRANES MADE FROM THE SAME CLIC1, CLIC4, CLCN2 KMT2A 207/4885MEN1 954/4885MAPK1 4385/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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