CLIC1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL4699731	1.00	2/20
SCHEMBL4697866	0.89	2/20
SCHEMBL4697696	0.86	2/20
SCHEMBL4699947	0.83	2/20
SCHEMBL4699140	0.80	2/20
SCHEMBL4922941	0.80	2/20
SCHEMBL4916509	0.78	2/20
SCHEMBL4700123	0.77	2/20
SCHEMBL4698636	0.76	2/20
SCHEMBL4914334	0.76	2/20
SCHEMBL4917606	0.76	2/20
SCHEMBL4908396	0.74	2/20
SCHEMBL4699183	0.74	2/20
SCHEMBL4914310	0.73	2/20
SCHEMBL4915098	0.73	2/20
SCHEMBL4696222	0.72	2/20
SCHEMBL4701699	0.70	2/20
SCHEMBL4698169	0.70	2/20
SCHEMBL4696537	0.68	2/20
SCHEMBL4920392	0.66	2/20

Clinical trials — most relevant to CLIC1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy and Safety of Tigerase® vs. Pulmozyme® in Patients With Cystic Fibrosis	PHASE3	COMPLETED
Safety, Tolerability, and Efficacy of PLX-200 in Patients With CLN3	PHASE3	NOT_YET_RECRUITING
Intravitreal ERT to Prevent Retinal Disease Progression in Children With CLN2	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
Safety and Tolerability of Inhaled Nitric Oxide in Patients With Cystic Fibrosis	PHASE1/PHASE2	COMPLETED
Aerosolized Hypertonic Xylitol Versus Hypertonic Saline in Cystic Fibrosis (CF) Subjects	PHASE1/PHASE2	COMPLETED
Inhaled Xylitol Versus Saline in Stable Subjects With Cystic Fibrosis	PHASE1/PHASE2	COMPLETED
Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis	EARLY_PHASE1	RECRUITING
Mechanism and Effects of Manipulating Chloride Homeostasis in Stable Heart Failure	EARLY_PHASE1	COMPLETED
Examining Developmental Outcomes of Children Diagnosed With CLN2 Disease	nan	ENROLLING_BY_INVITATION
A Natural History Study of RYR1-Related Disorders	nan	RECRUITING
Natural History of Neuronal Ceroid Lipofuscinosis, Batten's CLN6 Diseae	nan	ACTIVE_NOT_RECRUITING
Microbiome Acquisition and Progression of Inflammation and Airway Disease in Infants and Children With Cystic Fibrosis	nan	COMPLETED
Investigations of Juvenile Neuronal Ceroid Lipofuscinosis	nan	RECRUITING
Comparison Between Ultra-low-dose Computed Tomography and Lung MRI in Cystic Fibrosis	nan	COMPLETED
Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or Palate	nan	RECRUITING
The Effect of Adding Lubiprostone to Standard Large-Volume PEG-ELS on The Quality of Inpatient Colonoscopy Preparation	nan	WITHDRAWN
Development of an Artificial Intelligence Algorithm to Detect Pathological Repolarization Disorders on the ECG and the Risk of Ventricular Arrhythmias	nan	RECRUITING
Wolfram Syndrome and WFS1-related Disorders International Registry and Clinical Study	nan	RECRUITING
Genetic Analysis of Craniosynostosis, Philadelphia Type	nan	COMPLETED
Genome Sequencing in the Intensive Care Unit Population	nan	ENROLLING_BY_INVITATION
A Single Center Prospective Study in an Estimated 570 Patients Who Underwent Genetic Screening at UZ Brussel in the Context of a Primary Cardiac Arrhythmia. Patients Showing a Variant Class 3,4 or 5 in SCN4A or CLCN1 Will Undergo a Clinical and Electrophysiological Review After IC.	nan	NOT_YET_RECRUITING
Energy Balance and Weight Gain With Ivacaftor Treatment	nan	COMPLETED
Na+ Channel mRNA Regulation in Heart Failure	nan	COMPLETED
Bone Microarchitecture at the Radius: a Pilot Comparison Between Children With Cystic Fibrosis and Healthy Controls	nan	COMPLETED
Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts	nan	COMPLETED
Genomic Sequencing for Evaluation of Fetal Structural Anomalies	nan	ENROLLING_BY_INVITATION
Neurogenetics Patient Registry	nan	RECRUITING
Gastrostomy-Biliary Diversion: Innovative Management for Bile Canalicular Transport Disorders	nan	UNKNOWN
Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis.	nan	COMPLETED
Genetic Analysis of Parkinson's Disease	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CLIC1 binder may also engage these)

Protein	Name	Similarity
Q9Z1Q5	—	1.000	Q9Z1Q5 →
Q6MG61	—	1.000	Q6MG61 →
Q5E9B7	—	1.000	Q5E9B7 →
Q95MF9	—	1.000	Q95MF9 →
Q9EPT8	—	0.997	Q9EPT8 →
Q9Z0W7	—	0.996	Q9Z0W7 →
Q5M883	—	0.996	Q5M883 →
Q5R957	—	0.994	Q5R957 →
CLIC4	Chloride intracellular channel protein 4	0.994	landscape →
Q9FG59	—	0.993	Q9FG59 →
Q9XSA7	—	0.993	Q9XSA7 →
Q9QYB1	—	0.993	Q9QYB1 →
Q8BXK9	—	0.992	Q8BXK9 →
O15247	—	0.991	O15247 →
Q6NLB0	—	0.990	Q6NLB0 →
P25317	—	0.989	P25317 →
Q9D7P7	—	0.988	Q9D7P7 →
O45405	—	0.988	O45405 →
Q65XA0	—	0.987	Q65XA0 →
Q4WB03	—	0.987	Q4WB03 →
A0A1U8QXK4	—	0.987	A0A1U8QXK4 →
O95833	—	0.987	O95833 →
Q9FUT0	—	0.986	Q9FUT0 →
P34277	—	0.986	P34277 →
Q10N44	—	0.985	Q10N44 →
Q9C8M3	—	0.985	Q9C8M3 →
P49248	—	0.985	P49248 →
Q9LZ06	—	0.984	Q9LZ06 →
Q29238	—	0.984	Q29238 →
GSTA1	Glutathione S-transferase A1	0.984	landscape →