Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
| ▸ | CHUK | O15111 | 1/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | PAK4 | O96013 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | PRKACA | P17612 | 1/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.52 |
| ▸ | LTK | P29376 | 1/20 | 0.52 |
| ▸ | GRK5 | P34947 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.52 |
| ▸ | CDK8 | P49336 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2879644 | 1.00 | IKBKB (0.52) | IKBKBCHUKDAPK3JAK2PRKD3 | |
| Hydrochloric Acid SCHEMBL3793579 | 1.00 | IKBKB (0.52) | IKBKBCHUKDAPK3JAK2PRKD3 | |
| SCHEMBL28859500 | 0.98 | IKBKB (0.53) | IKBKBCHUKDAPK3JAK2PRKD3 | |
| SCHEMBL28868 | 0.98 | IKBKB (0.53) | IKBKBCHUKDAPK3JAK2PRKD3 | |
| Benzene SCHEMBL28095234 | 0.98 | IKBKB (0.53) | IKBKBCHUKDAPK3JAK2PRKD3 | |
| Water SCHEMBL3156497 | 0.96 | LRRK2 (0.49) | IKBKBCHUKDAPK3JAK2PRKD3 | |
| Water SCHEMBL6948377 | 0.96 | LRRK2 (0.49) | IKBKBCHUKDAPK3JAK2PRKD3 | |
| SCHEMBL9448814 | 0.96 | IKBKB (0.52) | IKBKBCHUKDAPK3JAK2PRKD3 | |
| Hydrochloric Acid SCHEMBL8685286 | 0.96 | IKBKB (0.52) | IKBKBCHUKDAPK3JAK2PRKD3 | |
| SCHEMBL5341478 | 0.96 | IKBKB (0.52) | IKBKBCHUKDAPK3JAK2PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192448-B1 | PROCESS OF USING A SENSOR PLATFORM | NOVARTIS AG (CH) | 2006-09-27 | — | — | EP | claimed |
| US-6771376-B2 | ANALYSING SAMPLES, AFFINITY SENSING, DNA, PROTEIN, PEPTIDE AND ANTIBODY CHIP TECHNOLOGY | NOVARTIS AG (CH) | 2004-08-03 | — | — | US | claimed |
| US-20040115825-A1 | Substrate with thin, optical transparent layer; variations in refractive index; corrugated structure | BUDACH WOLFGANG ERNST GUSTAV (DE) | 2004-06-17 | — | — | US | claimed |
| US-20040115826-A1 | Detector on substrate; variations in refractive index | BUDACH WOLFGANG ERNST GUSTAV (DE) | 2004-06-17 | — | — | US | claimed |
| EP-1029233-B1 | MEASURING THE CONCENTRATION OF A SUBSTANCE | CANCER RES CAMPAIGN TECH (GB) | 2003-03-19 | — | — | EP | claimed |
| US-6531097-B1 | For determining the concentration of oxygen within living tissue cells; For example, the fluorescence of the fluorophor tris(4,7-diphenyl-1,10-phenanthroline) ruthenium chloride is decreased in inverse to concentration of oxygen | CANCER RESEARCH CAMPAIGN TECHNOLOGY, LTD. (GB) | 2003-03-11 | — | — | US | claimed |
| US-6469785-B1 | Optical detection device based on semi-conductor laser array | ZEPTOSENS AG (CH) | 2002-10-22 | — | — | US | claimed |
| US-20020135780-A1 | Sensor platform, apparatus incorporating the platform, and process using the platform | NOVARTIS AG (CH) | 2002-09-26 | — | — | US | claimed |
| EP-1192448-A1 | SENSOR PLATFORM, APPARATUS INCORPORATING THE PLATFORM, AND PROCESS USING THE PLATFORM | Novartis AG (CH) | 2002-04-03 | — | — | EP | claimed |
| WO-2001002839-A1 | SENSOR PLATFORM, APPARATUS INCORPORATING THE PLATFORM, AND PROCESS USING THE PLATFORM | NOVARTIS AG (CH) | 2001-01-11 | — | — | WO | claimed |
| EP-0918984-A1 | OPTICAL DETECTOR | Novartis AG (CH) | 1999-06-02 | — | — | EP | claimed |
| WO-1998008077-A1 | OPTICAL DETECTOR | NOVARTIS AG (CH) | 1998-02-26 | — | — | WO | claimed |
| EP-0824684-A1 | SENSOR PLATFORM AND METHOD FOR THE PARALLEL DETECTION OF A PLURALITY OF ANALYTES USING EVANESCENTLY EXCITED LUMINESCENCE | Novartis AG (CH) | 1998-02-25 | — | — | EP | claimed |
| WO-1996035940-A1 | SENSOR PLATFORM AND METHOD FOR THE PARALLEL DETECTION OF A PLURALITY OF ANALYTES USING EVANESCENTLY EXCITED LUMINESCENCE | NOVARTIS AG (CH) | 1996-11-14 | — | — | WO | claimed |
| CN-116283739-A | Ionic metal ruthenium complex, preparation method and application thereof | 中国科学院化学研究所 | 2023-06-23 | — | — | CN | disclosed |
| EP-2596337-B1 | CONCENTRATION MEASUREMENT USING LUMINESCENCE | OXFORD OPTRONIX LTD (GB) | 2021-02-24 | — | — | EP | disclosed |
| US-9207176-B2 | Concentration measurement using luminescence | OXFORD OPTRONIX LTD. (GB) | 2015-12-08 | — | — | US | disclosed |
| WO-1995033198-A1 | PROCESS FOR DETECTING EVANESCENTLY EXCITED LUMINESCENCE | CIBA-GEIGY AG (CH) | 1995-12-07 | — | — | WO | disclosed |
| WO-1995033197-A1 | PROCESS FOR DETECTING EVANESCENTLY EXCITED LUMINESCENCE | CIBA-GEIGY AG (CH) | 1995-12-07 | — | — | WO | disclosed |
| US-5152287-A | Cross-linked fluorinated polymers for use in gas sensors | CORDIS CORPORATION (US) | 1992-10-06 | — | — | US | disclosed |