Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.72 |
| ▸ | PKM | P14618 | 1/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | OGA | O60502 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22570306 | 1.00 | ALDH1A1 (0.72) | ALDH1A1KDM4EPKMCYP1A2CYP2D6 | |
| SCHEMBL664734 | 0.92 | ALDH1A1 (0.84) | ALDH1A1KDM4EPKMCYP1A2CYP2D6 | |
| SCHEMBL22076979 | 0.92 | ALDH1A1 (0.84) | ALDH1A1KDM4EPKMCYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL4795566 | 0.90 | ALDH1A1 (0.87) | ALDH1A1KDM4EPKMCYP1A2CYP2D6 | |
| SCHEMBL22570158 | 0.88 | ALDH1A1 (0.72) | ALDH1A1KDM4EPKMCYP1A2CYP2D6 | |
| SCHEMBL8226104 | 0.85 | ALDH1A1 (0.97) | ALDH1A1KDM4EPKMCYP1A2CYP2D6 | |
| SCHEMBL12384586 | 0.85 | ALDH1A1 (0.68) | ALDH1A1KDM4EPKMCYP1A2CYP2D6 | |
| SCHEMBL22570159 | 0.85 | ALDH1A1 (0.73) | ALDH1A1KDM4EPKMCYP1A2CYP2D6 | |
| SCHEMBL14934960 | 0.84 | ALDH1A1 (0.72) | ALDH1A1KDM4EPKMCYP1A2CYP2D6 | |
| SCHEMBL14931725 | 0.84 | ALDH1A1 (0.72) | ALDH1A1KDM4EPKMCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461328-B2 | Tricyclic heterocyclic compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20110201593-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| US-20110201593-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201593-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | CCNY, CCNA1, CCNA2 | ALDH1A1 1168/4885KDM4E 2333/4885PKM 1313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.