Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 5/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.52 |
| ▸ | RXRA | P19793 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | GLA | P06280 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4896265 | 0.94 | NR1H2 (0.61) | NR1H2NR1H3RXRAALDH1A1HPGD | |
| SCHEMBL2266112 | 0.94 | NR1H2 (0.56) | NR1H2NR1H3RXRAALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL4896145 | 0.94 | NR1H2 (0.60) | NR1H2NR1H3RXRAALDH1A1HPGD | |
| SCHEMBL2268665 | 0.91 | NR1H2 (0.50) | NR1H2NR1H3RXRAALDH1A1HPGD | |
| SCHEMBL2262363 | 0.90 | NR1H2 (0.52) | NR1H2NR1H3RXRAALDH1A1HPGD | |
| SCHEMBL2264755 | 0.90 | NR1H2 (0.52) | NR1H2NR1H3RXRAALDH1A1HPGD | |
| SCHEMBL2262884 | 0.90 | NR1H2 (0.52) | NR1H2NR1H3RXRAALDH1A1HPGD | |
| SCHEMBL2263811 | 0.90 | NR1H2 (0.59) | NR1H2NR1H3RXRAALDH1A1HPGD | |
| SCHEMBL4904761 | 0.89 | NR1H2 (0.52) | NR1H2NR1H3RXRAALDH1A1HPGD | |
| SCHEMBL2262644 | 0.88 | RXRA (0.58) | NR1H2NR1H3RXRAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |