Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Chlorphentermine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 0.95 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.95 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.95 |
| ▸ | HTR2A | P28223 | 1/20 | 0.95 |
| ▸ | HRH1 | P35367 | 1/20 | 0.95 |
| ▸ | HTR2B | P41595 | 1/20 | 0.95 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.95 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 4/20 | 0.45 |
| ▸ | AGXT | P21549 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorphentermine SCHEMBL160516 | 0.98 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3HTR2AHRH1 | |
| Chlorphentermine SCHEMBL1885131 | 0.93 | SLC6A2 (0.91) | SLC6A2SLC6A4SLC6A3HTR2AHRH1 | |
| Chlorphentermine SCHEMBL10801397 | 0.91 | SLC6A4 (0.88) | SLC6A2SLC6A4SLC6A3HTR2AHRH1 | |
| Chlorphentermine SCHEMBL21773282 | 0.88 | SLC6A2 (0.81) | SLC6A2SLC6A4SLC6A3HTR2AHRH1 | |
| Hydrochloric Acid SCHEMBL5831539 | 0.81 | SLC6A2 (0.64) | SLC6A2SLC6A4SLC6A3HTR2AHRH1 | |
| SCHEMBL14040447 | 0.80 | SLC6A4 (0.69) | SLC6A2SLC6A4SLC6A3HTR2AHRH1 | |
| Hydrochloric Acid SCHEMBL3638960 | 0.79 | SLC6A2 (0.61) | SLC6A2SLC6A4SLC6A3HTR2AHRH1 | |
| Hydrochloric Acid SCHEMBL8528672 | 0.79 | SLC6A2 (0.61) | SLC6A2SLC6A4SLC6A3HTR2AHRH1 | |
| Hydrochloric Acid SCHEMBL8528039 | 0.78 | SLC6A2 (0.61) | SLC6A2SLC6A4SLC6A3HTR2AHRH1 | |
| SCHEMBL73498 | 0.78 | SLC6A4 (0.67) | SLC6A2SLC6A4SLC6A3HTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 207 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220170019-A1 | NANOSYSTEM BASED ON MICRORNA FOR TREATING OBSESITY | UNIVERSIDAD DE MÁLAGA (ES) | 2022-06-02 | — | — | US | claimed |
| EP-3960859-A1 | NANOSYSTEM BASED ON MICRORNA FOR TREATING OBSESITY | Servicio Andaluz De Salud (ES) | 2022-03-02 | — | — | EP | claimed |
| WO-2020165482-A1 | NANOSYSTEM BASED ON MICRORNA FOR TREATING OBSESITY | SERVICIO ANDALUZ DE SALUD (ES) | 2020-08-20 | — | — | WO | claimed |
| CN-101590063-A | The application of tanshinone in the medicine of preparation treatment obesity and insulin resistant | SHANGHAI GARMENT GROUP BRAND D (CN) | 2009-12-02 | — | — | CN | claimed |
| CN-101371837-A | Uses of B vitamins nicotinic amide in regulating body weight, blood sugar and insulin sensibility | SHANGHAI INST BIOL SCIENCES (CN) | 2009-02-25 | — | — | CN | claimed |
| CN-101264095-A | Application of polydatin in preventing and controlling obesity and relieving insulin resistance | SHANGHAI INST BIOL SCIENCES (CN) | 2008-09-17 | — | — | CN | claimed |
| CN-1072965-C | Improved topical delivery of drugs | PROCTER & GAMBLE (US) | 2001-10-17 | — | — | CN | claimed |
| CN-1050763-C | Enhanced skin penetration system for improved topical delivery of drugs | RICHARDSON VICKS INC (US) | 2000-03-29 | — | — | CN | claimed |
| EP-0608322-B1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON VICKS INC (US) | 1998-07-22 | — | — | EP | claimed |
| US-5773023-A | BLEND OF AQUEOUS CARRIER, ACTIVE MATERIAL AND POLYACRYLAMIDE | RICHARDSON-VICKS INC. (US) | 1998-06-30 | — | — | US | claimed |
| EP-0608320-B1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON VICKS INC (US) | 1998-01-28 | — | — | EP | claimed |
| EP-0652774-B1 | PHARMACEUTICAL COMPOSITION FOR TOPICAL USE CONTAINING A CROSSLINKED CATIONIC POLYMER AND AN ALKOXYLATED ETHER | PROCTER & GAMBLE (US) | 1997-05-07 | — | — | EP | claimed |
| US-5614178-A | TRANSDERMAL | THE PROCTER & GAMBLE COMPANY (US) | 1997-03-25 | — | — | US | claimed |
| CN-1091317-A | Improve the part input of medicine | PROCTER & GAMBLE (US) | 1994-08-31 | — | — | CN | claimed |
| EP-0608322-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1994-08-03 | — | — | EP | claimed |
| EP-0608320-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1994-08-03 | — | — | EP | claimed |
| CN-1072863-A | Be used to improve the dermal osmosis system of the reinforcement of medicine localized delivery | RICHARDSON VICKS INC (US) | 1993-06-09 | — | — | CN | claimed |
| CN-1072602-A | Improve the enhanced dermal osmosis system of the local conveying of medicine | RICHARDSON VICKS INC (US) | 1993-06-02 | — | — | CN | claimed |
| WO-1993007902-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1993-04-29 | — | — | WO | claimed |
| WO-1993007903-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1993-04-29 | — | — | WO | claimed |