Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Chlorphentermine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 0.88 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.88 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.88 |
| ▸ | HTR2A | P28223 | 1/20 | 0.88 |
| ▸ | HRH1 | P35367 | 1/20 | 0.88 |
| ▸ | HTR2B | P41595 | 1/20 | 0.88 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.88 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorphentermine SCHEMBL160516 | 0.94 | SLC6A2 (1.00) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| Chlorphentermine SCHEMBL124013 | 0.91 | SLC6A2 (0.95) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| Chlorphentermine SCHEMBL1885131 | 0.89 | SLC6A2 (0.91) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| Chlorphentermine SCHEMBL21773282 | 0.84 | SLC6A2 (0.81) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL14040447 | 0.77 | SLC6A4 (0.69) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL3408632 | 0.77 | SLC6A2 (0.63) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL28848601 | 0.75 | SLC6A4 (0.67) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL228926 | 0.75 | SLC6A2 (0.67) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL73498 | 0.75 | SLC6A4 (0.67) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL6705712 | 0.75 | ALDH1A1 (0.61) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-59020641-A | — | — | None | — | — | JP | disclosed |
| US-10414883-B2 | Method for producing molded article, molded article, back plate and brake pad | SUMITOMO BAKELITE CO., LTD. (JP) | 2019-09-17 | — | — | US | disclosed |
| US-20170009031-A1 | METHOD FOR PRODUCING MOLDED ARTICLE, MOLDED ARTICLE, BACK PLATE AND BRAKE PAD | SUMITOMO BAKELITE CO., LTD. (JP) | 2017-01-12 | — | — | US | disclosed |
| US-4640937-A | Modified phenolic resin composition | SHOWA HIGHPOLYMER CO. LTD. (JP) | 1987-02-03 | — | — | US | disclosed |
| JP-S5920641-A | SHORTENING OF VULCANIZING TIME OF RUBBER PRODUCT | SUMITOMO RUBBER IND LTD | 1984-02-02 | — | — | JP | disclosed |
| JP-S05920641-A | — | — | 0001-01-01 | — | — | JP | disclosed |