Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 18/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12402568 | 0.85 | JAK3 (0.47) | JAK3JAK2JAK1SYK | |
| SCHEMBL12372398 | 0.85 | MAPK1 (0.44) | JAK3JAK2JAK1SYK | |
| SCHEMBL12146892 | 0.79 | JAK3 (0.71) | JAK3JAK2JAK1SYK | |
| SCHEMBL2275139 | 0.75 | SYK (0.66) | JAK3JAK2JAK1SYK | |
| SCHEMBL2278304 | 0.71 | JAK3 (0.51) | JAK3JAK2JAK1SYK | |
| SCHEMBL12441730 | 0.71 | JAK3 (0.43) | JAK3JAK2JAK1SYK | |
| SCHEMBL2281190 | 0.70 | JAK3 (0.50) | JAK3JAK2JAK1SYK | |
| SCHEMBL2281069 | 0.70 | JAK3 (0.47) | JAK3JAK2JAK1SYK | |
| SCHEMBL650177 | 0.69 | JAK3 (0.47) | JAK3 | |
| SCHEMBL12440686 | 0.69 | JAK3 (0.41) | JAK3JAK2JAK1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008298-B2 | Pyrrolopyrazine kinase inhibitors | Roche Palo Alto (US) | 2011-08-30 | — | — | US | disclosed |
| US-20100267666-A1 | Pyrrolopyrazine kinase inhibitors | ROCHE PALO ALTO LLC | 2010-10-21 | — | — | US | disclosed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267666-A1 | Pyrrolopyrazine kinase inhibitors | SYK, ZAP70, TYK2 | JAK3 7/4885JAK2 4/4885JAK1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.