Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 17/20 | 0.41 |
| ▸ | JAK2 | O60674 | 7/20 | 0.41 |
| ▸ | JAK1 | P23458 | 7/20 | 0.41 |
| ▸ | SYK | P43405 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12401528 | 0.99 | JAK3 (0.40) | JAK3JAK2JAK1SYK | |
| SCHEMBL13689712 | 0.99 | JAK3 (0.40) | JAK3JAK2JAK1SYK | |
| SCHEMBL649072 | 0.85 | MAPK1 (0.44) | JAK3JAK2JAK1SYK | |
| SCHEMBL651420 | 0.84 | MAPK1 (0.43) | JAK3JAK2JAK1SYK | |
| SCHEMBL648945 | 0.84 | MAPK1 (0.43) | JAK3JAK2JAK1SYK | |
| SCHEMBL12400305 | 0.79 | JAK3 (0.40) | JAK3JAK2JAK1 | |
| SCHEMBL12441451 | 0.78 | JAK3 (0.39) | JAK3JAK2JAK1 | |
| SCHEMBL3060951 | 0.76 | SYK (0.40) | JAK3JAK2JAK1SYK | |
| SCHEMBL2273795 | 0.76 | SYK (0.40) | JAK3JAK2JAK1SYK | |
| SCHEMBL3066002 | 0.76 | JAK3 (0.43) | JAK3JAK2JAK1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247593-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-10 | — | — | EP | disclosed |