Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.74 |
| ▸ | HRH1 | P35367 | 1/20 | 0.74 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL991736 | 0.85 | HRH3 (1.00) | HRH3HRH1S1PR1MAOBMAOA | |
| SCHEMBL29638864 | 0.83 | HRH3 (0.95) | HRH3HRH1S1PR1MAOBMAOA | |
| SCHEMBL2283302 | 0.78 | HRH3 (0.86) | HRH3HRH1S1PR1MAOBMAOA | |
| SCHEMBL3158896 | 0.77 | HRH3 (0.85) | HRH3HRH1S1PR1MAOBMAOA | |
| SCHEMBL7809741 | 0.72 | HRH1 (0.56) | HRH3HRH1S1PR1KDM4EALDH1A1 | |
| SCHEMBL7814084 | 0.72 | HRH1 (0.56) | HRH3HRH1S1PR1KDM4EALDH1A1 | |
| SCHEMBL12376850 | 0.69 | HRH3 (0.73) | HRH3HRH1MAOBMAOAKCNH2 | |
| Hydrochloric Acid SCHEMBL5935439 | 0.69 | HRH3 (0.65) | HRH3HRH1MAOBKCNH2CYP2C9 | |
| SCHEMBL7804406 | 0.68 | S1PR1 (0.57) | HRH3HRH1S1PR1 | |
| SCHEMBL4670302 | 0.67 | HRH3 (0.72) | HRH3MAOBKCNH2CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989629-B2 | 3-(4-{ [4-(4-{ [3-(3, 3-dimethyl-1-piperidinyl) propyl] oxy} phenyl)-1-piperidinyl] carbonyl}-1-naphthalenyl) propanoic or propenoic acid as H1 and H3 receptor antagonists for the treatment of inflammatory and/or allergic disorders | GLAXO GROUP LIMITED (GB) | 2011-08-02 | — | — | US | disclosed |
| US-20080312280-A1 | 3- (4-{ [4- (4-{ [3-(3, 3-Dimethyl-1-Piperidinyl) Propyl] Oxy} Phenyl) -1-Piperidinyl] Carbonyl}-1-Naphthalenyl) Propanoic or Propenoic Acid as H1 and H3 Receptor Antagonists for the Treatment of Inflammatory and/or Allergic Disorders | GLAXO GROUP LIMITED (GB) | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312280-A1 | 3- (4-{ [4- (4-{ [3-(3, 3-Dimethyl-1-Piperidinyl) Propyl] Oxy} Phenyl) -1-Piperidinyl] Carbonyl}-1-Naphthalenyl) Propanoic or Propenoic Acid as H1 and H3 Receptor Antagonists for the Treatment of Inflammatory and/or Allergic Disorders | HRH3, HRH1, HRH2 | HRH3 1/4885HRH1 2/4885S1PR1 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.