Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 19/20 | 0.60 |
| ▸ | AKT2 | P31751 | 19/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2356455 | 0.92 | AKT1 (0.62) | AKT1AKT2KCNH2 | |
| SCHEMBL1501777 | 0.90 | AKT1 (0.58) | AKT1AKT2KCNH2 | |
| SCHEMBL2281065 | 0.89 | AKT1 (0.56) | AKT1AKT2KCNH2 | |
| SCHEMBL5499246 | 0.87 | AKT1 (0.75) | AKT1AKT2KCNH2 | |
| SCHEMBL1057503 | 0.87 | AKT1 (0.59) | AKT1AKT2KCNH2 | |
| SCHEMBL1059047 | 0.86 | KCNH2 (0.76) | AKT1AKT2KCNH2 | |
| SCHEMBL2281488 | 0.86 | AKT1 (0.78) | AKT1AKT2KCNH2 | |
| Hydrochloric Acid SCHEMBL1501644 | 0.86 | KCNH2 (0.75) | AKT1AKT2KCNH2 | |
| SCHEMBL5497263 | 0.85 | AKT1 (0.75) | AKT1AKT2KCNH2 | |
| SCHEMBL12759242 | 0.85 | KCNH2 (0.53) | AKT1AKT2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008317-B2 | Inhibitors of akt activtiy | MERCK SHARP & DOHME CORP. (US) | 2011-08-30 | — | — | US | disclosed |
| US-20100222321-A1 | Inhibitors of akt activtiy | MERCK SHARP & DOHME LLC | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222321-A1 | Inhibitors of akt activtiy | PIK3CA, PIK3CD, INPP5D | AKT1 8/4885AKT2 4/4885KCNH2 3672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.