Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 19/20 | 0.75 |
| ▸ | AKT2 | P31751 | 19/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.54 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5499246 | 0.94 | AKT1 (0.75) | AKT1AKT2KCNH2AKT3 | |
| SCHEMBL2356455 | 0.86 | AKT1 (0.62) | AKT1AKT2KCNH2 | |
| SCHEMBL1137849 | 0.86 | AKT1 (0.59) | AKT1AKT2KCNH2AKT3 | |
| SCHEMBL12410248 | 0.85 | AKT1 (0.60) | AKT1AKT2KCNH2 | |
| SCHEMBL2271522 | 0.85 | AKT1 (0.58) | AKT1AKT2KCNH2AKT3 | |
| SCHEMBL1059047 | 0.84 | KCNH2 (0.76) | AKT1AKT2KCNH2 | |
| SCHEMBL1138090 | 0.84 | AKT1 (0.54) | AKT1AKT2KCNH2AKT3 | |
| Hydrochloric Acid SCHEMBL1501644 | 0.83 | KCNH2 (0.75) | AKT1AKT2KCNH2 | |
| SCHEMBL1501777 | 0.83 | AKT1 (0.58) | AKT1AKT2KCNH2 | |
| SCHEMBL2281065 | 0.83 | AKT1 (0.56) | AKT1AKT2KCNH2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1827436-A2 | INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006065601-A2 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2006-06-22 | — | — | WO | claimed |