Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 7/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 2/20 | 0.38 |
| ▸ | GIPR | P48546 | 2/20 | 0.38 |
| ▸ | GLP1R | P43220 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1241501 | 0.87 | SERPINE1 (0.54) | SERPINE1ALOX5PTGESNR1H4GCGR | |
| SCHEMBL1239090 | 0.87 | SERPINE1 (0.57) | SERPINE1ALOX5PTGESNR1H4PSEN1 | |
| SCHEMBL1241436 | 0.85 | SERPINE1 (0.56) | SERPINE1ALOX5PTGESNR1H4GCGR | |
| SCHEMBL1241600 | 0.84 | SERPINE1 (0.51) | SERPINE1ALOX5PTGESNR1H4PSEN1 | |
| SCHEMBL1241732 | 0.84 | SERPINE1 (0.51) | SERPINE1ALOX5PTGESNR1H4PSEN1 | |
| SCHEMBL1242737 | 0.83 | SERPINE1 (0.50) | SERPINE1ALOX5PTGESNR1H4GCGR | |
| SCHEMBL1241530 | 0.83 | SERPINE1 (0.56) | SERPINE1ALOX5PTGESNR1H4GCGR | |
| SCHEMBL1241427 | 0.83 | PTGES (0.53) | SERPINE1ALOX5PTGESNR1H4CYP19A1 | |
| SCHEMBL1241578 | 0.82 | SERPINE1 (0.49) | SERPINE1ALOX5PTGESNR1H4PTPN1 | |
| SCHEMBL1241736 | 0.82 | SERPINE1 (0.53) | SERPINE1ALOX5PTGESNR1H4GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7884234-B2 | N-[4-(tert-butyl)benzyl]-N-[4 -(trifluoromethoxy)biphenyl-3-yl]oxamic Acid; Inhibitors of plasminogen activator inhibitor-1 (PAI-1); thrombogenesis, fibrogenesis, accumulation of visceral fat, cell proliferation, angiogenesis | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2011-02-08 | — | — | US | disclosed |