Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | VDR | P11473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22614877 | 0.81 | TRPA1 (0.70) | TRPA1SLC6A2TAAR1CYP2D6LMNA | |
| SCHEMBL11857650 | 0.81 | TRPA1 (0.59) | TRPA1SLC6A2TAAR1CYP2D6LMNA | |
| SCHEMBL11616261 | 0.81 | TRPA1 (0.59) | TRPA1SLC6A2TAAR1CYP2D6LMNA | |
| SCHEMBL11700362 | 0.80 | TRPA1 (0.46) | TRPA1SLC6A2TAAR1SLC6A4SLC6A3 | |
| SCHEMBL114928 | 0.78 | TRPA1 (0.71) | TRPA1SLC6A2TAAR1SLC6A4SLC6A3 | |
| SCHEMBL4977777 | 0.77 | TRPA1 (0.54) | TRPA1SLC6A2TAAR1CYP2D6LMNA | |
| SCHEMBL3594929 | 0.75 | CYP3A4 (0.48) | TRPA1SLC6A2TAAR1CYP2D6LMNA | |
| SCHEMBL4743524 | 0.75 | CYP3A4 (0.48) | TRPA1SLC6A2TAAR1CYP2D6LMNA | |
| SCHEMBL13765633 | 0.74 | TRPA1 (0.61) | TRPA1SLC6A2TAAR1SLC6A4SLC6A3 | |
| SCHEMBL11613544 | 0.74 | TRPA1 (0.56) | TRPA1SLC6A2TAAR1SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110172223-A1 | Substituted Aryl Sulfone Derivatives as Calcium Channel Blockers | CHAKRAVARTY PRASUN K | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172223-A1 | Substituted Aryl Sulfone Derivatives as Calcium Channel Blockers | TRPV1, TRPA1, CACNA1D | TRPA1 2/4885SLC6A2 474/4885TAAR1 348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.