Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PKLR | P30613 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12417665 | 1.00 | KDM4E (0.41) | KDM4EAKR1C3GRM2PKMPKLR | |
| SCHEMBL1724280 | 0.88 | GRM2 (0.44) | KDM4EAKR1C3GRM2PKMPKLR | |
| SCHEMBL2195008 | 0.88 | GRM2 (0.44) | KDM4EAKR1C3GRM2PKMPKLR | |
| SCHEMBL2195046 | 0.88 | GRM2 (0.44) | KDM4EAKR1C3GRM2PKMPKLR | |
| SCHEMBL2191626 | 0.85 | AKR1C3 (0.40) | KDM4EAKR1C3GRM2PKMPKLR | |
| SCHEMBL2191377 | 0.85 | AKR1C3 (0.40) | KDM4EAKR1C3GRM2PKMPKLR | |
| SCHEMBL2195484 | 0.83 | GRM5 (0.45) | KDM4EAKR1C3GRM2CNR1L3MBTL1 | |
| SCHEMBL2195921 | 0.83 | GRM5 (0.45) | KDM4EAKR1C3GRM2CNR1L3MBTL1 | |
| SCHEMBL2189802 | 0.82 | DPP4 (0.45) | KDM4EAKR1C3HTTHSD11B1DPP4 | |
| SCHEMBL12415654 | 0.82 | DPP4 (0.45) | KDM4EAKR1C3HTTHSD11B1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110172223-A1 | Substituted Aryl Sulfone Derivatives as Calcium Channel Blockers | CHAKRAVARTY PRASUN K | 2011-07-14 | — | — | US | disclosed |
| US-20110172223-A1 | Substituted Aryl Sulfone Derivatives as Calcium Channel Blockers | CHAKRAVARTY PRASUN K | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172223-A1 | Substituted Aryl Sulfone Derivatives as Calcium Channel Blockers | TRPV1, TRPA1, CACNA1D | KDM4E 1380/4885AKR1C3 1242/4885GRM2 446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.