Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.50 |
| ▸ | FEN1 | P39748 | 2/20 | 0.50 |
| ▸ | IDH2 | P48735 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.48 |
| ▸ | MTOR | P42345 | 5/20 | 0.48 |
| ▸ | PIK3C3 | Q8NEB9 | 4/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | PARG | Q86W56 | 1/20 | 0.46 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.45 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23953188 | 1.00 | KMT2A (0.56) | KMT2ATDP1ALDH1A1ALOX5APFEN1 | |
| SCHEMBL16728062 | 0.88 | PIK3CD (0.53) | ALDH1A1CYP3A4TSHRPIK3CDPIK3CB | |
| SCHEMBL2196383 | 0.87 | KMT2A (0.52) | KMT2ATDP1ALDH1A1ALOX5APFEN1 | |
| SCHEMBL2196387 | 0.87 | KMT2A (0.52) | KMT2ATDP1ALDH1A1ALOX5APFEN1 | |
| SCHEMBL16705632 | 0.86 | KMT2A (0.53) | KMT2ATDP1ALOX5APFEN1IDH2 | |
| SCHEMBL2196030 | 0.86 | KMT2A (0.53) | KMT2ATDP1ALOX5APFEN1IDH2 | |
| SCHEMBL2196024 | 0.86 | KMT2A (0.53) | KMT2ATDP1ALOX5APFEN1IDH2 | |
| SCHEMBL2194173 | 0.85 | ALOX5AP (0.54) | KMT2ATDP1ALOX5APFEN1IDH2 | |
| SCHEMBL2194991 | 0.85 | ALOX5AP (0.54) | KMT2ATDP1ALOX5APFEN1IDH2 | |
| SCHEMBL2194177 | 0.85 | ALOX5AP (0.54) | KMT2ATDP1ALOX5APFEN1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8435968-B2 | Aryl-phenyl-sulfonamido-cycloalkyl compounds and their use | PIMCO 2664 LIMITED (GB) | 2013-05-07 | — | — | US | disclosed |
| US-20110172189-A1 | Aryl-Phenyl-Sulfonamido-Cycloalkyl Compounds and Their Use | PIMCO 2664 LIMITED (GB) | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172189-A1 | Aryl-Phenyl-Sulfonamido-Cycloalkyl Compounds and Their Use | SOST, AADAC, ARSA | KMT2A 1816/4885TDP1 3674/4885ALDH1A1 3408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.