SOST

Sclerostin · Q9BQB4 · SOST on Sugi Atlas →

5,507 patent compounds predicted against SOST, 4,781 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
(+)-Taxifolin (SCHEMBL3405951)	0.78	3/20
Taxifolin (SCHEMBL39570)	1.00	2/20
(+)-Taxifolin (SCHEMBL39786)	1.00	2/20
Ampelopsin (SCHEMBL134531)	1.00	2/20
Ampelopsin (SCHEMBL134532)	1.00	2/20
(+)-Taxifolin (SCHEMBL296323)	1.00	2/20
Ampelopsin (SCHEMBL723736)	1.00	2/20
(+)-Taxifolin (SCHEMBL1707803)	1.00	2/20
Ampelopsin (SCHEMBL544092)	0.97	2/20
Dihydrokaempferol (SCHEMBL39319)	0.80	2/20
Dihydrokaempferol (SCHEMBL2036629)	0.80	2/20
Dihydrokaempferol (SCHEMBL3437565)	0.80	2/20
Dihydrokaempferol (SCHEMBL3438673)	0.80	2/20
Pinobaksin (SCHEMBL1045054)	0.75	2/20
Dicentrine (SCHEMBL679684)	0.72	2/20
SCHEMBL94263	0.71	2/20
SCHEMBL1067942	0.69	2/20
Fustin (SCHEMBL555237)	0.67	2/20
SCHEMBL3191589	0.65	2/20
SCHEMBL3362576	0.65	2/20

Clinical trials — most relevant to SOST by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Novel Combination Therapy for Osteoporosis in Men	PHASE4	ACTIVE_NOT_RECRUITING
Romosozumab Versus Denosumab for Osteoporosis in Long-term Glucocorticoid Users	PHASE4	COMPLETED
Efficacy of Romosozumab and Denosumab Combined Treatment in Postmenopausal Osteoporosis Patients with Multiple Fragility Fractures	PHASE4	NOT_YET_RECRUITING
Alterations of GCF Levels of Sclerostin and DKK-1 in Postmenopausal Osteoporosis	PHASE4	COMPLETED
Romosozumab Use to Build Skeletal Integrity	PHASE4	ACTIVE_NOT_RECRUITING
ADD-ON Study to Existing Hypoparathyroidism Studies	PHASE3	UNKNOWN
Functional Yogurt Powder Effect on Bone Health Biomarkers	PHASE3	COMPLETED
Setrusumab vs Bisphosphonates in Pediatric Subjects With Osteogenesis Imperfecta	PHASE3	ACTIVE_NOT_RECRUITING
Healthy Body, Healthy Bones After Bariatric Surgery Trial	PHASE1/PHASE2	COMPLETED
Role of Estrogen on Skeletal Outcomes in FHA	PHASE2	RECRUITING
Romosozumab to Improve Bone Mineral Density and Architecture in Chronic SCI	PHASE2	ACTIVE_NOT_RECRUITING
Denosumab and Male Infertility: a RCT	PHASE2	COMPLETED
Romosozumab/Denosumab Study for Premenopausal IOP	PHASE2	ACTIVE_NOT_RECRUITING
Comparative Effect of Zoledronic Acid Versus Denosumab on Serum Sclerostin of Postmenopausal Women With Low Bone Mass	nan	COMPLETED
is the Sclerostin Marker of Chronic Periodontitis	nan	COMPLETED
Sclerostin and Vascular Calcification in CKD and Renal Transplant	nan	UNKNOWN
Bone and Cardiovascular Disease After Kidney Transplant	nan	UNKNOWN
The Bone-parathyroid Crosstalk in Primary Hyperparathyroidism	nan	UNKNOWN
Serum Sclerostin Levels, Cardiovascular Parameters and Carpal Tunnel Syndrome in Maintenance Hemodialysis Patients	nan	UNKNOWN
Effect of Bone on Vibration-Induced Muscle Strength Gain	nan	COMPLETED
Planetary Habitat Simulation: Bone Metabolism Studies	nan	COMPLETED
Characterising Pain, QoL, Body Composition, Arterial Stiffness, Muscles and Bones in Adult Persons With XLH and Healthy Controls	nan	COMPLETED
Bone Turnover in Type 2 Diabetes and Non-diabetes Controls (DiaMarv)	nan	COMPLETED
The Effects of Hemodialysis on Serum Sclerostin Levels	nan	COMPLETED
Study to Weigh the Effect of Exercise Training on BONE (SWEET-BONE) Quality and Strength in Type 2 Diabetes	nan	COMPLETED
The Role Of FGF23, Klotho, And Sclerostin In Kidney Stone Formers	nan	UNKNOWN
Systematic Study of Parameters of Chronic Kidney Disease Mineral and Bone Disorder (CKD-MBD)	nan	UNKNOWN
Cycling Duration and Bone Markers in in Active Young Adults	nan	WITHDRAWN
Effect of Non-Surgical Periodontal Therapy on Salivary Biomarkers in Smokers and Non-Smokers With Periodontitis	nan	RECRUITING
Optimizing Telehealth-delivery of a Weight Loss Intervention in Older Adults	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a SOST binder may also engage these)

Protein	Name	Similarity
Q9BG78	—	1.000	Q9BG78 →
Q9BG79	—	1.000	Q9BG79 →
Q99P67	—	1.000	Q99P67 →
Q99P68	—	1.000	Q99P68 →
P12919	—	0.989	P12919 →
P49766	—	0.989	P49766 →
P20675	—	0.988	P20675 →
Q5R5D2	—	0.987	Q5R5D2 →
Q95229	—	0.987	Q95229 →
P35054	—	0.987	P35054 →
P97946	—	0.987	P97946 →
Q6J936	—	0.987	Q6J936 →
P43026	—	0.986	P43026 →
Q9YHT8	—	0.986	Q9YHT8 →
P67965	—	0.986	P67965 →
Q6Q7I7	—	0.986	Q6Q7I7 →
P58239	—	0.986	P58239 →
P67964	—	0.986	P67964 →
P85315	—	0.985	P85315 →
P01139	—	0.985	P01139 →
Q58T08	—	0.985	Q58T08 →
C0K3N3	—	0.985	C0K3N3 →
Q5ISB0	—	0.985	Q5ISB0 →
P67860	—	0.985	P67860 →
P67861	—	0.985	P67861 →
Q6X4U4	—	0.985	Q6X4U4 →
P25427	—	0.985	P25427 →
P49765	—	0.985	P49765 →
Q9N2F1	—	0.985	Q9N2F1 →
Q9Z1W4	—	0.985	Q9Z1W4 →