Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.49 |
| ▸ | RAB9A | P51151 | 12/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 3/20 | 0.44 |
| ▸ | F2 | P00734 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | F9 | P00740 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12419733 | 0.93 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2TP53LMNA | |
| SCHEMBL12420209 | 0.93 | F10 (0.44) | NPC1RAB9ASMN1; SMN2TP53LMNA | |
| SCHEMBL2297559 | 0.91 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2TP53LMNA | |
| SCHEMBL12421963 | 0.90 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2TP53LMNA | |
| SCHEMBL12419731 | 0.89 | RAB9A (0.46) | NPC1RAB9ASMN1; SMN2TP53LMNA | |
| SCHEMBL2299707 | 0.89 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2TP53LMNA | |
| SCHEMBL12420237 | 0.86 | RAB9A (0.51) | NPC1RAB9AKMT2AMEN1PPARG | |
| SCHEMBL12420946 | 0.85 | KHK (0.44) | NPC1RAB9AF10F2KMT2A | |
| SCHEMBL2296240 | 0.84 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2TP53LMNA | |
| SCHEMBL2300721 | 0.83 | F10 (0.44) | NPC1RAB9ASMN1; SMN2TP53F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003806-B2 | Integrin antagonists useful as anticancer agents | OSI Pharmaceuticals, LLC (US) | 2011-08-23 | — | — | US | disclosed |