Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PNLIP | P16233 | 4/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12420305 | 0.93 | MEN1 (0.44) | MEN1KMT2AHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL2295738 | 0.89 | MEN1 (0.45) | MEN1KMT2AHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL12420191 | 0.89 | KMT2A (0.50) | KMT2AALDH1A1GAA | |
| SCHEMBL12420299 | 0.85 | FADS1 (0.44) | MEN1KMT2AHSD17B10ALDH1A1ADRA2B | |
| SCHEMBL2294085 | 0.85 | MAPT (0.47) | MEN1KMT2AHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL12420928 | 0.84 | NPC1 (0.41) | MEN1KMT2AHSD17B10ALDH1A1ADRA2B | |
| SCHEMBL2296390 | 0.82 | MEN1 (0.45) | MEN1KMT2AHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL12421967 | 0.81 | NR1I2 (0.45) | MEN1KMT2AHSD17B10ALDH1A1NPC1 | |
| SCHEMBL12420930 | 0.81 | NR1I2 (0.45) | MEN1KMT2AHSD17B10ALDH1A1NPC1 | |
| SCHEMBL12420935 | 0.80 | ATM (0.43) | MEN1KMT2AHSD17B10ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003806-B2 | Integrin antagonists useful as anticancer agents | OSI Pharmaceuticals, LLC (US) | 2011-08-23 | — | — | US | disclosed |