Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.40 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2297563 | 0.92 | NPC1 (0.43) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL5306613 | 0.86 | PTGFR (0.39) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL2358248 | 0.85 | SMN1; SMN2 (0.45) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL5306619 | 0.85 | TRPV1 (0.38) | NPC1RAB9AMEN1KMT2ARXFP1 | |
| SCHEMBL2298688 | 0.79 | NPC1 (0.48) | NPC1RAB9AMEN1KMT2AMAPK1 | |
| SCHEMBL2299134 | 0.79 | NPC1 (0.49) | NPC1RAB9AKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL12421965 | 0.76 | KMT2A (0.46) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2297594 | 0.76 | PRNP (0.41) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5304516 | 0.76 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2297445 | 0.75 | ALDH1A1 (0.47) | NPC1RAB9AMEN1KMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003806-B2 | Integrin antagonists useful as anticancer agents | OSI Pharmaceuticals, LLC (US) | 2011-08-23 | — | — | US | disclosed |