Sugi Predict

Sugi Predict / Compounds / SCHEMBL1242219

SCHEMBL1242219

SCHEMBL1242219

CC(C)(C)c1ccc(CN(C(=O)C(=O)O)c2ccccc2Oc2ccc(OC(F)(F)F)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ SERPINE1 P05121 6/20 0.54
▸ GCGR P47871 2/20 0.47
▸ GIPR P48546 2/20 0.47
▸ GLP1R P43220 1/20 0.47
▸ EPHX2 P34913 1/20 0.46
▸ NR1H4 Q96RI1 1/20 0.46
▸ SLC6A2 P23975 1/20 0.44
▸ SLC6A4 P31645 1/20 0.44
▸ SLC6A3 Q01959 1/20 0.44
▸ PPARG P37231 1/20 0.43
▸ PPARA Q07869 1/20 0.43
▸ MEN1 O00255 2/20 0.41
▸ KMT2A Q03164 2/20 0.41
▸ LPAR1 Q92633 2/20 0.41
▸ LPAR5 Q9H1C0 2/20 0.41
▸ RAB9A P51151 1/20 0.41
▸ TRPV1 Q8NER1 1/20 0.41
▸ TSPO P30536 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1241646 0.90 EPHX2 (0.47) SERPINE1GCGRGIPRGLP1REPHX2
SCHEMBL1239797 0.86 SERPINE1 (0.46) SERPINE1GCGRGIPRGLP1REPHX2
SCHEMBL1242204 0.86 SERPINE1 (0.60) SERPINE1GCGRGIPRGLP1REPHX2
SCHEMBL1242527 0.84 SERPINE1 (0.66) SERPINE1GCGRGIPRGLP1REPHX2
SCHEMBL1241436 0.83 SERPINE1 (0.56) SERPINE1GCGRGIPRGLP1REPHX2
SCHEMBL1241613 0.82 SERPINE1 (0.49) SERPINE1GCGRGIPRGLP1REPHX2
SCHEMBL1241639 0.81 SERPINE1 (0.54) SERPINE1GCGRGIPRGLP1REPHX2
SCHEMBL1241718 0.81 SERPINE1 (0.54) SERPINE1GCGRGIPRGLP1REPHX2
SCHEMBL1242687 0.81 SERPINE1 (0.56) SERPINE1GCGRGIPRGLP1REPHX2
SCHEMBL12952826 0.81 NR1H4 (0.45) SERPINE1GCGRGIPRGLP1REPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7884234-B2 N-[4-(tert-butyl)benzyl]-N-[4 -(trifluoromethoxy)biphenyl-3-yl]oxamic Acid; Inhibitors of plasminogen activator inhibitor-1 (PAI-1); thrombogenesis, fibrogenesis, accumulation of visceral fat, cell proliferation, angiogenesis INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) 2011-02-08 — — US disclosed
US-20090215899-A9 N-Phenyloxamide derivatives INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) 2009-08-27 — — US disclosed
EP-2072498-A1 N-PHENYLOXAMIDIC ACID DERIVATIVE Institute of Medicinal Molecular Design, Inc. (JP) 2009-06-24 — — EP disclosed
US-20080249175-A1 N-Phenyloxamide derivatives INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) 2008-10-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080249175-A1 N-Phenyloxamide derivatives SERPINE1, SERPINH1, F12 SERPINE1 1/4885GCGR 1724/4885GIPR 2082/4885
US-20090215899-A9 N-Phenyloxamide derivatives SERPINE1, SERPINH1, F12 SERPINE1 1/4885GCGR 1724/4885GIPR 2082/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.