Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SI | P14410 | 1/20 | 0.50 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
| ▸ | KDM5C | P41229 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.43 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14513982 | 0.87 | MGAM (0.41) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL1783362 | 0.87 | ALDH1A1 (0.53) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL1783361 | 0.87 | ALDH1A1 (0.53) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL1786444 | 0.85 | — | — | |
| SCHEMBL2128645 | 0.82 | MGAM (0.56) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL1608 | 0.82 | — | — | |
| SCHEMBL10389469 | 0.82 | MGAM (0.56) | MGAMGAASIMGAM2ALDH1A1 | |
| Water SCHEMBL23151837 | 0.78 | MGAM (0.53) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL22325638 | 0.78 | — | — | |
| SCHEMBL1005355 | 0.78 | MGAM (0.53) | MGAMGAASIMGAM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977430-B2 | Prepared by reacting an amine- or isocyanate-capped polyurea with a multifunctional compound having at least one one ethylenically unsaturated group and a function group coreactive with the capping amine or isocyanate groups of the polyurea; soft contact lenses; durability | NOVARTIS AG (CH) | 2011-07-12 | — | — | US | disclosed |