Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.63 |
| ▸ | KDR | P35968 | 14/20 | 0.63 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | STK25 | O00506 | 1/20 | 0.51 |
| ▸ | CIT | O14578 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | CHUK | O15111 | 1/20 | 0.51 |
| ▸ | MUSK | O15146 | 1/20 | 0.51 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | PAK3 | O75914 | 1/20 | 0.51 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.51 |
| ▸ | STK10 | O94804 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1790130 | 0.95 | MET (0.69) | METKDRPLK4STK25CIT | |
| SCHEMBL14748585 | 0.82 | MET (0.56) | METKDRPLK4STK25CIT | |
| SCHEMBL1790131 | 0.81 | MET (0.49) | METKDRPLK4STK25CIT | |
| SCHEMBL30498610 | 0.79 | MET (0.61) | METKDRPLK4STK25CIT | |
| SCHEMBL30498615 | 0.79 | MET (0.61) | METKDRPLK4STK25CIT | |
| SCHEMBL10108314 | 0.79 | MET (0.61) | METKDRPLK4STK25CIT | |
| SCHEMBL12424217 | 0.77 | MET (0.62) | METKDRPLK4STK25CIT | |
| SCHEMBL12411691 | 0.76 | EPHX2 (0.51) | METKDRAURKAFLT1FLT4 | |
| SCHEMBL13548249 | 0.76 | MET (0.49) | METKDRPLK4STK25CIT | |
| SCHEMBL14742487 | 0.76 | MET (0.55) | METKDRPLK4STK25CIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977345-B2 | c-MET modulators and method of use | EXELIXIS, INC. (US) | 2011-07-12 | — | — | US | disclosed |