Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12922352 | 0.86 | ALDH1A1 (0.67) | ALDH1A1LMNAAGTR1KMT2AHPGD | |
| SCHEMBL27406305 | 0.84 | ALDH1A1 (0.59) | ALDH1A1LMNAAGTR1KMT2AHPGD | |
| SCHEMBL12790929 | 0.82 | ALDH1A1 (0.50) | ALDH1A1LMNAAGTR1KMT2AMEN1 | |
| SCHEMBL12384542 | 0.82 | ALDH1A1 (0.47) | ALDH1A1LMNAAGTR1KMT2AMEN1 | |
| SCHEMBL12859265 | 0.81 | KMT2A (0.64) | ALDH1A1LMNAKMT2AMAPTTP53 | |
| SCHEMBL8735354 | 0.80 | ALDH1A1 (0.48) | ALDH1A1LMNAAGTR1KMT2AMEN1 | |
| SCHEMBL8247021 | 0.80 | KMT2A (0.62) | ALDH1A1LMNAKMT2ACYP3A4CYP2C19 | |
| SCHEMBL18419027 | 0.80 | KMT2A (0.47) | ALDH1A1LMNAAGTR1KMT2AMEN1 | |
| SCHEMBL25674596 | 0.79 | ALDH1A1 (0.47) | ALDH1A1LMNAAGTR1KMT2ACYP2C19 | |
| SCHEMBL9381303 | 0.79 | ALDH1A1 (0.69) | ALDH1A1KMT2AMAPTCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461328-B2 | Tricyclic heterocyclic compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20110201593-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201593-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | CCNY, CCNA1, CCNA2 | ALDH1A1 1168/4885LMNA 1043/4885AGTR1 1489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.