Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR2 | Q969V1 | 9/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.37 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13000675 | 0.83 | MCHR2 (0.44) | MCHR2DRD2SLC6A4KCNH2 | |
| SCHEMBL13207758 | 0.83 | MCHR2 (0.44) | MCHR2DRD2SLC6A4KCNH2 | |
| SCHEMBL13001193 | 0.83 | MCHR2 (0.44) | MCHR2DRD2SLC6A4KCNH2 | |
| SCHEMBL2758090 | 0.83 | MCHR2 (0.52) | MCHR2DRD2SLC6A4KCNH2ALDH1A1 | |
| SCHEMBL13000505 | 0.83 | MCHR2 (0.44) | MCHR2DRD2SLC6A4KCNH2 | |
| SCHEMBL13000018 | 0.83 | SIGMAR1 (0.51) | MCHR2DRD2SLC6A4KCNH2 | |
| SCHEMBL240547 | 0.82 | MCHR2 (0.46) | MCHR2DRD2SLC6A4KCNH2HSD11B1 | |
| SCHEMBL2758104 | 0.82 | MCHR2 (0.52) | MCHR2DRD2SLC6A4KCNH2ALDH1A1 | |
| SCHEMBL240548 | 0.82 | MCHR2 (0.46) | MCHR2DRD2SLC6A4KCNH2HSD11B1 | |
| SCHEMBL2758065 | 0.82 | MCHR2 (0.50) | MCHR2DRD2SLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003660-B2 | Modulators of muscarinic receptors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-08-23 | — | — | US | disclosed |