Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 18/20 | 0.42 |
| ▸ | ACVR1B | P36896 | 12/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 11/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12425352 | 0.96 | IDO1 (0.43) | NR4A2TGFBR1ACVR1BACVRL1IDO1 | |
| SCHEMBL12424676 | 0.90 | TGFBR1 (0.46) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL12424816 | 0.89 | TGFBR1 (0.44) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL12424766 | 0.87 | TGFBR1 (0.41) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL12424765 | 0.85 | TGFBR1 (0.45) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL3383010 | 0.84 | IDO1 (0.42) | NR4A2TGFBR1ACVR1BACVRL1IDO1 | |
| SCHEMBL2298025 | 0.82 | EGFR (0.42) | TGFBR1 | |
| SCHEMBL12424824 | 0.82 | TGFBR1 (0.58) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL12425335 | 0.82 | TGFBR1 (0.46) | TGFBR1 | |
| SCHEMBL12424777 | 0.81 | EGFR (0.43) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2539336-B1 | HETARYLAMINONAPHTHYRIDINES | MERCK PATENT GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |
| US-8815893-B2 | Hetarylaminonaphthyridines | MERCK PATENT GMBH (DE) | 2014-08-26 | — | — | US | disclosed |
| US-8815893-B2 | Hetarylaminonaphthyridines | MERCK PATENT GMBH (DE) | 2014-08-26 | — | — | US | disclosed |
| US-20120316166-A1 | HETARYLAMINONAPHTHYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-12-13 | — | — | US | disclosed |
| US-20120316166-A1 | HETARYLAMINONAPHTHYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-12-13 | — | — | US | disclosed |
| WO-2011101069-A2 | HETARYLAMINONAPHTHYRIDINES | MERCK PATENT GMBH (DE) | 2011-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120316166-A1 | HETARYLAMINONAPHTHYRIDINES | ATP5ME, ATP5F1A, ATP5F1D | NR4A2 2543/4885TGFBR1 3742/4885ACVR1B 4144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.