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TGFBR1

TGF-beta receptor type-1 · P36897 · TGFBR1 on Sugi Atlas →

162,096 patent compounds predicted against TGFBR1, 87,954 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Hydrochloric Acid Hydrochloric Acid (SCHEMBL140197) 1.00 20/20
SCHEMBL142081 SCHEMBL142081 1.00 20/20
SCHEMBL246517 SCHEMBL246517 1.00 20/20
SCHEMBL246830 SCHEMBL246830 1.00 20/20
SCHEMBL246861 SCHEMBL246861 1.00 20/20
SCHEMBL247145 SCHEMBL247145 1.00 20/20
SCHEMBL247160 SCHEMBL247160 1.00 20/20
SCHEMBL247412 SCHEMBL247412 1.00 20/20
SCHEMBL247976 SCHEMBL247976 1.00 20/20
SCHEMBL248190 SCHEMBL248190 1.00 20/20
SCHEMBL248193 SCHEMBL248193 1.00 20/20
SCHEMBL248262 SCHEMBL248262 1.00 20/20
SCHEMBL248307 SCHEMBL248307 1.00 20/20
SCHEMBL248450 SCHEMBL248450 1.00 20/20
SCHEMBL248592 SCHEMBL248592 1.00 20/20
SCHEMBL248684 SCHEMBL248684 1.00 20/20
SCHEMBL248723 SCHEMBL248723 1.00 20/20
SCHEMBL248811 SCHEMBL248811 1.00 20/20
SCHEMBL248819 SCHEMBL248819 1.00 20/20
SCHEMBL248945 SCHEMBL248945 1.00 20/20

Clinical trials — most relevant to TGFBR1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Adrenocorticotropic Hormone (ACTH) Treatment of Nephrotic Range Proteinuria in Diabetic Nephropathy (NRDN) PHASE4COMPLETED
The Effect of Ramipril in Suppressing ST2 Expression in Rheumatic Mitral Stenosis Patients PHASE3UNKNOWN
Evaluation of Irbesartan on Hepatic Fibrosis in Chronic Hepatitis C PHASE3COMPLETED
Placebo-Controlled Randomized Study of KW-3902 for Subjects Hospitalized With Worsening Renal Function and Heart Failure Requiring IV Therapy PHASE3COMPLETED
Luspatercept in Preventing Poor Erythroid Engraftment for Hematological Malignancies With Moderate to Severe Myelofibrosis PHASE2/PHASE3NOT_YET_RECRUITING
A Trial of Tadalafil in Interstitial Lung Disease of Scleroderma PHASE3COMPLETED
Phase 2 Study of Bintrafusp Alfa in Recurrent/Metastatic Olfactory Neuroblastoma (BARON). PHASE2COMPLETED
Efficacy and Safety of Oltipraz in the Patients With Liver Fibrosis and Cirrhosis PHASE2COMPLETED
A Study to Evaluate the Safety and Efficacy of Vactosertib and Imatinib in Patients With Advanced Desmoid Tumor PHASE1/PHASE2COMPLETED
Antitumor Activity of Neoadjuvant Chemotherapy with or Without HCW9218 in Metastatic Advanced Stage Ovarian Cancer PHASE2WITHDRAWN
M7824 and Topotecan or Temozolomide in Relapsed Small Cell Lung Cancers PHASE1/PHASE2COMPLETED
M7824 in Subjects With HPV Associated Malignancies PHASE2COMPLETED
Safety and Imaging Study of GC1008 in Glioma PHASE2COMPLETED
Phase I/II Trial Investigating the Safety, Tolerability, Pharmacokinetics, Immune and Clinical Activity of SX-682 in Combination With BinTrafusp Alfa (M7824 or TGF-beta Trap/PD-L1) With CV301 TRICOM in Advanced Solid Tumors (STAT) PHASE1/PHASE2COMPLETED
Phase II Study of Vandetanib in Individuals With Kidney Cancer PHASE2COMPLETED
A First-in-Human, Phase 1 Dose-Escalation and Cohort Expansion Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of BJ-005 in Patients With Advanced Solid Tumor or Lymphoma PHASE1UNKNOWN
HPV-16/18 E6/E7-Specific T Lymphocytes, Relapsed HPV-Associated Cancers, HESTIA PHASE1COMPLETED
Safety of Fresolimumab in the Treatment of Osteogenesis Imperfecta PHASE1COMPLETED
Bintrafusp Alfa (M7824) and PDS01ADC Alone and in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Metastatic Non-Prostate Genitourinary Malignancies PHASE1RECRUITING
Phase I/II for Safety and Efficacy of Nilotinib in a Population Steroid-refractory/or Steroid-dependent cGVHD PHASE1COMPLETED
Effect of Aloe Vera Gel and Manuka Honey on Radiation Induced Oral Mucositis nanUNKNOWN
Assessment of the TGF-beta Pathway and Micro-RNA in Pediatric Pulmonary Arterial Hypertension nanUNKNOWN
Circulating Activin-A and FSTL3 in Precapillary Pulmonary Hypertension nanACTIVE_NOT_RECRUITING
Physiopathology of Pulmonary Arterial Hypertension: Mechanistic Studies nanUNKNOWN
Baker Cyst Aspiration Combined With Platelet-rich Plasma Injection in Knee Osteoarthritis nanCOMPLETED
Angiotensin II Antagonism of TGF-Beta 1 nanCOMPLETED
Biomarker Levels During Indwelling Pleural cAtheter Sample Testing nanENROLLING_BY_INVITATION
Luspatercept in Metastatic AGCT of the Ovary nanCOMPLETED
Pharmacogenomics of Interferon and Ribavirin Treatment in Patients With Chronic Hepatitis C Virus Infection nanUNKNOWN
Effect of Montelukast on the Expression and Variation of TGF-β for Children With Mild Persistent Asthma nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a TGFBR1 binder may also engage these)

ProteinNameSimilarity
Q64729 — 1.000 Q64729 →
P80204 — 1.000 P80204 →
O46680 — 1.000 O46680 →
P80202 — 1.000 P80202 →
Q61271 — 1.000 Q61271 →
BMPR1B Bone morphogenetic protein receptor type-1B 1.000 landscape →
Q5CD18 — 1.000 Q5CD18 →
Q05438 — 1.000 Q05438 →
P70539 — 1.000 P70539 →
ACVR1B Activin receptor type-1B 1.000 landscape →
Q78EA7 — 1.000 Q78EA7 →
P37172 — 0.999 P37172 →
P80201 — 0.999 P80201 →
Q90ZK6 — 0.997 Q90ZK6 →
P36898 — 0.997 P36898 →
Q8NER5 — 0.996 Q8NER5 →
P80203 — 0.996 P80203 →
Q8K348 — 0.995 Q8K348 →
Q28041 — 0.995 Q28041 →
P36895 — 0.995 P36895 →
Q61288 — 0.993 Q61288 →
BMPR1A Bone morphogenetic protein receptor type-1A 0.993 landscape →
Q24468 — 0.991 Q24468 →
Q60629 — 0.991 Q60629 →
ACVR1 Activin receptor type-1 0.990 landscape →
Q5RAN0 — 0.989 Q5RAN0 →
ACVRL1 Activin receptor type-1-like 0.987 landscape →
P54757 — 0.986 P54757 →
A1Z7L8 — 0.985 A1Z7L8 →
EPHA5 Ephrin type-A receptor 5 0.985 landscape →