Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.50 |
| ▸ | MTOR | P42345 | 2/20 | 0.50 |
| ▸ | SPR | P35270 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.42 |
| ▸ | FEN1 | P39748 | 2/20 | 0.42 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12426766 | 0.94 | PIK3CA (0.46) | PIK3CAMTORSPRALOX5APFEN1 | |
| SCHEMBL12425408 | 0.86 | PIK3CA (0.41) | PIK3CAMTORALOX5APFEN1TRPC6 | |
| SCHEMBL12425779 | 0.86 | KMT5A (0.43) | PIK3CAMTORTRPC6KMT5A | |
| SCHEMBL12425620 | 0.84 | CYP3A4 (0.41) | PIK3CAMTORHRH2HRH1MEN1 | |
| SCHEMBL12426765 | 0.82 | KMT5A (0.39) | PIK3CAMTORKMT5A | |
| SCHEMBL12425803 | 0.80 | DPP4 (0.43) | PIK3CAMTORKMT5A | |
| SCHEMBL2301926 | 0.79 | HDAC1 (0.48) | PIK3CAMTORSPRALOX5APFEN1 | |
| SCHEMBL2300794 | 0.78 | HDAC1 (0.52) | SPRHDAC1MEN1KMT2AGPR119 | |
| SCHEMBL1990029 | 0.77 | KMT2A (0.57) | MEN1KMT2AGPR119 | |
| SCHEMBL12425594 | 0.77 | HDAC1 (0.46) | PIK3CAMTORSPRHDAC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101409-A1 | PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF CDK4/6 | NOVARTIS AG (CH) | 2011-08-25 | — | — | WO | disclosed |