Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.37 |
| ▸ | MTOR | P42345 | 4/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12426765 | 0.87 | KMT5A (0.39) | KMT5AADRA1AL3MBTL3L3MBTL1LMNA | |
| SCHEMBL12425614 | 0.86 | PIK3CA (0.50) | KMT5APIK3CAMTORTRPC6 | |
| SCHEMBL12425803 | 0.86 | DPP4 (0.43) | KMT5AADRA1AL3MBTL3L3MBTL1LMNA | |
| SCHEMBL12426766 | 0.82 | PIK3CA (0.46) | LMNAPIK3CAMTOR | |
| SCHEMBL12425408 | 0.80 | PIK3CA (0.41) | KMT5AALDH1A1PIK3CAMTORTRPC6 | |
| SCHEMBL12425620 | 0.80 | CYP3A4 (0.41) | PIK3CAMTOR | |
| SCHEMBL29230264 | 0.74 | SMN1; SMN2 (0.50) | ALDH1A1PIK3CAMTORGRM5HPGD | |
| SCHEMBL31697636 | 0.74 | SMN1; SMN2 (0.50) | ALDH1A1PIK3CAMTORGRM5HPGD | |
| SCHEMBL12425404 | 0.74 | L3MBTL3 (0.51) | L3MBTL3L3MBTL1PIK3CAMTORHPGD | |
| SCHEMBL12425600 | 0.73 | CHRNA4 (0.60) | L3MBTL3L3MBTL1GABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101409-A1 | PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF CDK4/6 | NOVARTIS AG (CH) | 2011-08-25 | — | — | WO | disclosed |