Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | LIPC | P11150 | 1/20 | 0.30 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14300062 | 0.78 | — | — | |
| SCHEMBL7908107 | 0.75 | CRBN (0.32) | CRBN | |
| SCHEMBL13366457 | 0.74 | NPC1 (0.33) | S1PR1SGPL1 | |
| SCHEMBL31612215 | 0.72 | TRPA1 (0.44) | TRPA1 | |
| SCHEMBL28117788 | 0.71 | TRPA1 (0.43) | TRPA1 | |
| SCHEMBL1574372 | 0.70 | CRBN (0.36) | S1PR1SGPL1CRBNLIPCLIPG | |
| SCHEMBL14899262 | 0.68 | — | — | |
| SCHEMBL20053890 | 0.68 | DRD3 (0.47) | S1PR1SGPL1 | |
| SCHEMBL10278211 | 0.67 | S1PR1 (0.36) | S1PR1SGPL1CRBN | |
| SCHEMBL2606649 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2351754-B1 | PHENANTHROINDOLIZIDINE COMPOUND AND NF kB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT | YAKULT HONSHA KK (JP) | 2015-06-24 | — | — | EP | disclosed |
| EP-2351754-A1 | PHENANTHROINDOLIZIDINE COMPOUND AND NF B INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT | Kabushiki Kaisha Yakult Honsha (JP) | 2011-08-03 | — | — | EP | disclosed |