Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.78 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.78 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.78 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.78 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.78 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.78 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.78 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.78 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.78 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.78 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.78 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.78 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.78 |
| ▸ | FBP1 | P09467 | 1/20 | 0.77 |
| ▸ | ILK | Q13418 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 3/20 | 0.59 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.58 |
| ▸ | RET | P07949 | 1/20 | 0.58 |
| ▸ | KIF5B | P33176 | 1/20 | 0.58 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10118726 | 0.91 | HDAC3 (0.89) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL10118728 | 0.90 | EGFR (0.73) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL1507616 | 0.88 | EGFR (1.00) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL642027 | 0.88 | HDAC3 (1.00) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL14964660 | 0.87 | EGFR (0.83) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL1507764 | 0.87 | EGFR (0.98) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL642190 | 0.86 | EGFR (0.80) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL644023 | 0.85 | EGFR (0.83) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL12426808 | 0.85 | HDAC3 (0.69) | EGFRERBB2HDAC3HDAC4HDAC1 | |
| SCHEMBL2615523 | 0.85 | EGFR (0.80) | EGFRERBB2HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9108929-B2 | Quinazoline based EGFR inhibitors | CURIS, INC. (US) | 2015-08-18 | — | — | US | disclosed |
| US-9108929-B2 | Quinazoline based EGFR inhibitors | CURIS, INC. (US) | 2015-08-18 | — | — | US | disclosed |
| US-8349856-B2 | Quinazoline based EGFR inhibitors | CURIS, INC. (US) | 2013-01-08 | — | — | US | disclosed |
| US-7977347-B2 | inhibitors of epidermal growth factor receptor tyrosine kinase; anticancer; 6-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)hexanoic acid | CURIS, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-20080125448-A1 | Quinazoline Based EGFR Inhibitors Containing a Zinc Binding Moiety | CURIS, INC. | 2008-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125448-A1 | Quinazoline Based EGFR Inhibitors Containing a Zinc Binding Moiety | EGFR, ERBB2, ERBB4 | EGFR 1/4885ERBB2 2/4885HDAC3 3186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.