Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 15/20 | 0.69 |
| ▸ | HDAC4 | P56524 | 15/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 15/20 | 0.69 |
| ▸ | HDAC7 | Q8WUI4 | 15/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 15/20 | 0.69 |
| ▸ | HDAC10 | Q969S8 | 15/20 | 0.69 |
| ▸ | HDAC11 | Q96DB2 | 15/20 | 0.69 |
| ▸ | HDAC8 | Q9BY41 | 15/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.69 |
| ▸ | HDAC9 | Q9UKV0 | 15/20 | 0.69 |
| ▸ | HDAC5 | Q9UQL6 | 15/20 | 0.69 |
| ▸ | EGFR | P00533 | 8/20 | 0.69 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.69 |
| ▸ | KDR | P35968 | 10/20 | 0.62 |
| ▸ | GAK | O14976 | 1/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.62 |
| ▸ | BUB1 | O43683 | 1/20 | 0.62 |
| ▸ | STK10 | O94804 | 1/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | LCK | P06239 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12426807 | 0.99 | HDAC3 (0.70) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL8212465 | 0.91 | HDAC3 (0.84) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL12426815 | 0.90 | HDAC3 (0.58) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL12426818 | 0.89 | HDAC3 (0.59) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL12426799 | 0.85 | EGFR (0.84) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL12426796 | 0.85 | EGFR (0.78) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL12426798 | 0.84 | EGFR (0.84) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL3875759 | 0.84 | EGFR (0.80) | EGFRERBB2KDRGAKRIPK2 | |
| SCHEMBL8212082 | 0.82 | HDAC3 (0.70) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL642027 | 0.82 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9108929-B2 | Quinazoline based EGFR inhibitors | CURIS, INC. (US) | 2015-08-18 | — | — | US | disclosed |
| US-9108929-B2 | Quinazoline based EGFR inhibitors | CURIS, INC. (US) | 2015-08-18 | — | — | US | disclosed |
| US-8349856-B2 | Quinazoline based EGFR inhibitors | CURIS, INC. (US) | 2013-01-08 | — | — | US | disclosed |
| US-8349856-B2 | Quinazoline based EGFR inhibitors | CURIS, INC. (US) | 2013-01-08 | — | — | US | disclosed |
| US-7977347-B2 | inhibitors of epidermal growth factor receptor tyrosine kinase; anticancer; 6-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)hexanoic acid | CURIS, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-7977347-B2 | inhibitors of epidermal growth factor receptor tyrosine kinase; anticancer; 6-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)hexanoic acid | CURIS, INC. (US) | 2011-07-12 | — | — | US | disclosed |