SCHEMBL12427047

SCHEMBL12427047

CCOC(=O)Cc1c(CC)nc2c(S(=O)(=O)c3ccccc3)c(NC)nn2c1CC

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 20/20 0.60
HTR2B P41595 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12427110 0.86 HTR6 (0.53) HTR6HTR2B
SCHEMBL12428356 0.85 HTR6 (0.81) HTR6
SCHEMBL12441292 0.81 HTR6 (0.73) HTR6HTR2B
SCHEMBL12428367 0.78 HTR6 (0.72) HTR6
SCHEMBL12514575 0.75 HTR6 (1.00) HTR6
SCHEMBL12514932 0.75 HTR6 (0.73) HTR6
SCHEMBL12427161 0.75 HTR6 (0.73) HTR6
SCHEMBL12428379 0.75 HTR6 (0.71) HTR6
SCHEMBL12427357 0.73 HTR6 (0.81) HTR6
SCHEMBL12428381 0.72 HTR6 (1.00) HTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3020719-B1 SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS AND METHODS FOR THE PRODUCTION AND USE THEREOF AND METHODS FOR THE PRODUCTION AND USE THEREOF ALLA CHEM LLC (US) 2017-09-20 EP disclosed
EP-3020719-A1 SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS AND METHODS FOR THE PRODUCTION AND USE THEREOFAND METHODS FOR THE PRODUCTION AND USE THEREOF Alla Chem, LLC. (US) 2016-05-18 EP disclosed
EP-2351756-A1 SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS AND METHODS FOR THE PRODUCTION AND USE THEREOF Ivashchenko, Andrey Alexandrovich (RU) 2011-08-03 EP disclosed
WO-2010041983-A1 SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS AND METHODS FOR THE PRODUCTION AND USE THEREOF АЛЛА ХЕМ, ЛЛС (US) 2010-04-15 WO disclosed