Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.48 |
| ▸ | MMP12 | P39900 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.43 |
| ▸ | CCKBR | P32239 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL804154 | 1.00 | PRKCA (0.48) | PRKCAMMP12CHRM2CHRM4CHRM1 | |
| SCHEMBL804590 | 1.00 | PRKCA (0.48) | PRKCAMMP12CHRM2CHRM4CHRM1 | |
| SCHEMBL10283571 | 1.00 | PRKCA (0.48) | PRKCAMMP12CHRM2CHRM4CHRM1 | |
| SCHEMBL10283570 | 1.00 | PRKCA (0.48) | PRKCAMMP12CHRM2CHRM4CHRM1 | |
| SCHEMBL12427575 | 0.94 | PRKCA (0.48) | PRKCAMMP12CHRM2CHRM4CHRM1 | |
| SCHEMBL12427595 | 0.93 | PRKCA (0.48) | PRKCAMMP12CHRM2CHRM4CHRM1 | |
| SCHEMBL12427594 | 0.93 | PRKCA (0.48) | PRKCAMMP12CHRM2CHRM4CHRM1 | |
| SCHEMBL804122 | 0.93 | PRKCA (0.46) | PRKCAMMP12CHRM2CHRM4CHRM1 | |
| SCHEMBL12427618 | 0.93 | PRKCA (0.49) | PRKCAMMP12CHRM2CHRM4CHRM1 | |
| SCHEMBL10283262 | 0.93 | PRKCA (0.48) | PRKCAMMP12CHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| EP-2206715-A1 | Fused heterotetracyclic compounds and use thereof as hcv polymerase inhibitor | Japan Tobacco, Inc. (JP) | 2010-07-14 | — | — | EP | disclosed |