PRKCA — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Balanol (SCHEMBL62128)	1.00	20/20
Balanol (SCHEMBL62129)	1.00	20/20
Dequalinium (SCHEMBL34043)	0.97	13/20
SCHEMBL1255	0.80	13/20
SCHEMBL1704	0.65	11/20
Rebeccamycin (SCHEMBL24695)	0.84	10/20
SCHEMBL3834	0.52	10/20
SCHEMBL5448	0.52	10/20
SCHEMBL15952	0.52	10/20
SCHEMBL24214	0.52	10/20
SCHEMBL1977	1.00	9/20
Staurosporine (SCHEMBL8156)	1.00	9/20
Staurosporine (SCHEMBL8157)	1.00	9/20
SCHEMBL9197	1.00	9/20
SCHEMBL9338	1.00	9/20
SCHEMBL9838	0.79	9/20
SCHEMBL1442	0.78	9/20
SCHEMBL1365	0.66	9/20
SCHEMBL15364	0.43	9/20
SCHEMBL16201	0.43	9/20

Clinical trials — most relevant to PRKCA by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity	PHASE4	COMPLETED
Clinical Evaluation of the Effect of Metformin in Sepsis	PHASE3	UNKNOWN
Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients	PHASE3	ACTIVE_NOT_RECRUITING
Evaluate Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients	PHASE3	COMPLETED
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients	PHASE1/PHASE2	WITHDRAWN
PKC412 and 5-Azacytidine	PHASE1/PHASE2	COMPLETED
I/II Phase Study Evaluating M1774 in Combination With Fulvestrant in HR+ and HER2- Advanced Breast Cancers	PHASE1/PHASE2	NOT_YET_RECRUITING
Metformin and Simvastatin Use in Bladder Cancer	PHASE2	UNKNOWN
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old	PHASE2	ACTIVE_NOT_RECRUITING
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals	PHASE1/PHASE2	COMPLETED
Metformin Hydrochloride in Preventing Esophageal Cancer in Patients With Barrett Esophagus	PHASE2	COMPLETED
Sirolimus and Gold Sodium Thiomalate in Treating Patients With Advanced Squamous Non-Small Cell Lung Cancer	PHASE1	WITHDRAWN
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer	EARLY_PHASE1	COMPLETED
Possible Diagnostic Protein Markers in Schistosoma Related Bladder Diseases.	nan	NOT_YET_RECRUITING
Free Fatty Acid Induced Insulin Resistance	nan	COMPLETED
Defective Atypical Protein Kinase C (PKC) Activation in Diabetes and Metabolic Syndrome	nan	COMPLETED
Duality of Lipids: the Athlete's Paradox	nan	COMPLETED
Ischemic Preconditioning to Prevent Acute Kidney Injury	nan	COMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
Role of Nitric Oxide in Diabetic Patients With Erectile Dysfunction	nan	COMPLETED
Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH	nan	COMPLETED
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
Novel Inhibitors of Lipolysis in the Treatment of Lipid a Glucose Metabolism in Obstructive Sleep Apnea Syndrome	nan	UNKNOWN
Effect of Age on Glucose and Lipid Metabolism	nan	COMPLETED
Effect of Esterogen Receptor Modulator on Gene in Bipolar Diseas	nan	NOT_YET_RECRUITING
Influence of Intermittent Hypoxia on Glycemic Control	nan	COMPLETED
The Phosphodiesterase-3 Inhibitor Cilostazol as an Adjunctive to Antidepressants in Patients With Major Depressive Disorder.	nan	COMPLETED
Cardiac and Skeletal Muscle Energy Metabolism in Abnormal Growth Hormone States	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PRKCA binder may also engage these)

Protein	Name	Similarity
P05696	—	1.000	P05696 →
P10102	—	1.000	P10102 →
PRKCB	Protein kinase C beta type	1.000	landscape →
P04409	—	1.000	P04409 →
P20444	—	1.000	P20444 →
A8KBH6	—	1.000	A8KBH6 →
Q16974	—	1.000	Q16974 →
P68403	—	1.000	P68403 →
Q7SY24	—	1.000	Q7SY24 →
P05130	—	1.000	P05130 →
P68404	—	1.000	P68404 →
P90980	—	1.000	P90980 →
P05772	—	1.000	P05772 →
Q25378	—	1.000	Q25378 →
P05126	—	1.000	P05126 →
Q7LZQ8	—	0.999	Q7LZQ8 →
P05128	—	0.997	P05128 →
P34885	—	0.995	P34885 →
PRKCE	Protein kinase C epsilon type	0.994	landscape →
P63319	—	0.994	P63319 →
P63318	—	0.994	P63318 →
P10829	—	0.994	P10829 →
P10830	—	0.994	P10830 →
P13678	—	0.994	P13678 →
Q4R4U2	—	0.993	Q4R4U2 →
P09216	—	0.993	P09216 →
P16054	—	0.993	P16054 →
Q16975	—	0.992	Q16975 →
PRKCG	Protein kinase C gamma type	0.992	landscape →
P09215	—	0.992	P09215 →