Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.49 |
| ▸ | MMP12 | P39900 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | CCKBR | P32239 | 3/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10283730 | 0.91 | PRKCA (0.47) | PRKCAMMP12SCN9ANR1I2POLB | |
| SCHEMBL12427821 | 0.91 | PRKCA (0.47) | PRKCAMMP12SCN9ANR1I2POLB | |
| SCHEMBL14253345 | 0.90 | PRKCA (0.49) | PRKCAMMP12PARP1SCN9ANR1I2 | |
| SCHEMBL12427728 | 0.90 | PRKCA (0.58) | PRKCAMMP12SCN9ANR1I2CSNK2A1 | |
| SCHEMBL804124 | 0.89 | PRKCA (0.49) | PRKCAMMP12SCN9ANR1I2CCKBR | |
| SCHEMBL803839 | 0.89 | PRKCA (0.49) | PRKCAMMP12SCN9ANR1I2CCKBR | |
| SCHEMBL803874 | 0.89 | PRKCA (0.49) | PRKCAMMP12SCN9ANR1I2CCKBR | |
| SCHEMBL803965 | 0.89 | PRKCA (0.49) | PRKCAMMP12SCN9ANR1I2CCKBR | |
| SCHEMBL12427636 | 0.89 | PRKCA (0.49) | PRKCAMMP12SCN9ANR1I2CCKBR | |
| SCHEMBL12427734 | 0.89 | PRKCA (0.49) | PRKCAMMP12SCN9ANR1I2CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| EP-2206715-A1 | Fused heterotetracyclic compounds and use thereof as hcv polymerase inhibitor | Japan Tobacco, Inc. (JP) | 2010-07-14 | — | — | EP | disclosed |