Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12427895 | 0.93 | PRKCA (0.45) | PRKCAMMP12SCN9ANR1I2DRD2 | |
| SCHEMBL12427971 | 0.93 | PRKCA (0.45) | PRKCAMMP12SCN9ANR1I2DRD2 | |
| SCHEMBL803833 | 0.93 | PRKCA (0.45) | PRKCAMMP12SCN9ANR1I2DRD2 | |
| SCHEMBL804612 | 0.93 | PRKCA (0.45) | PRKCAMMP12SCN9ANR1I2DRD2 | |
| SCHEMBL803814 | 0.90 | PRKCA (0.42) | PRKCAMMP12SCN9ANR1I2 | |
| SCHEMBL12427775 | 0.90 | PRKCA (0.42) | PRKCAMMP12SCN9ANR1I2DRD2 | |
| SCHEMBL10283202 | 0.89 | PRKCA (0.45) | PRKCAMMP12SCN9ANR1I2KDM4E | |
| SCHEMBL803874 | 0.89 | PRKCA (0.49) | PRKCAMMP12SCN9ANR1I2KDM4E | |
| SCHEMBL804124 | 0.89 | PRKCA (0.49) | PRKCAMMP12SCN9ANR1I2KDM4E | |
| SCHEMBL803839 | 0.89 | PRKCA (0.49) | PRKCAMMP12SCN9ANR1I2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |