Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.54 |
| ▸ | MMP12 | P39900 | 1/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CCKBR | P32239 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12428102 | 0.92 | PRKCA (0.59) | PRKCAMMP12NR1I2SCN9ACYP3A4 | |
| SCHEMBL12427928 | 0.92 | PRKCA (0.59) | PRKCAMMP12NR1I2SCN9ACYP3A4 | |
| SCHEMBL12427993 | 0.89 | PRKCA (0.57) | PRKCAMMP12NR1I2SCN9AKCNH2 | |
| SCHEMBL12427994 | 0.88 | PRKCA (0.57) | PRKCAMMP12NR1I2SCN9ACYP3A4 | |
| SCHEMBL12427996 | 0.88 | PRKCA (0.57) | PRKCAMMP12NR1I2SCN9AKCNH2 | |
| SCHEMBL804300 | 0.87 | PRKCA (0.59) | PRKCAMMP12NR1I2SCN9AKCNH2 | |
| SCHEMBL12427988 | 0.87 | PRKCA (0.57) | PRKCAMMP12NR1I2SCN9ACYP3A4 | |
| SCHEMBL12428105 | 0.87 | PRKCA (0.58) | PRKCAMMP12NR1I2SCN9ACYP3A4 | |
| SCHEMBL12427989 | 0.86 | PRKCA (0.54) | PRKCAMMP12NR1I2SCN9AKCNH2 | |
| SCHEMBL12427961 | 0.86 | PRKCA (0.57) | PRKCAMMP12NR1I2SCN9AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |