SCHEMBL12428481

SCHEMBL12428481

C=CC1COC(c2cnc(-c3ccc(CF)c(F)c3)nc2)OC1

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 1/20 0.32
CYP11B2 P19099 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13439470 0.85 CYP11B1 (0.34) CYP11B1CYP11B2
SCHEMBL13614598 0.81
SCHEMBL13614951 0.81
SCHEMBL12656124 0.80 CYP11B1 (0.30) CYP11B1CYP11B2
SCHEMBL12428174 0.77 HDAC1 (0.32)
SCHEMBL7028535 0.74 CYP11B1 (0.31) CYP11B1CYP11B2
SCHEMBL13615607 0.73 CYP11B1 (0.31) CYP11B1CYP11B2
SCHEMBL9366605 0.73 KDM1A (0.42) CYP11B1CYP11B2
SCHEMBL9366617 0.73 KDM1A (0.42) CYP11B1CYP11B2
SCHEMBL12428785 0.72 NPC1 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2351741-A1 PENTACYCLIC LIQUID CRYSTAL COMPOUND HAVING NITROGEN-CONTAINING HETEROCYCLIC RING, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT Chisso Corporation (JP) 2011-08-03 EP disclosed